مجله پزشکی دانشگاه علوم پزشکی تبریز
سال سی و سوم شماره 4 (پیاپی 94، مهر و آبان 1390)

Producing extended-spectrum beta-lactamases (ESBLs) is one of reasons for drug resistance occurrence in Pseudomonas aeruginosa isolates. The aim of the present study was to evaluate antibiotic sensitivity patterns and presence of bla VEB-1 gene in P. aerugionsa isolates collected from Imam Reza and Shahid Madani Hospitals of Tabriz, Iran.

During one year period (2008-2009), 85 isolates of P. aerugionsa were collected from ICUs of Imam Reza and Shahid Madani hospitals in Tabriz and identified by conventional bacteriological tests. The antibiotic sensitivity patterns of all isolates were determined. All isolates resistant to ceftazidim were selected for determining the ESBL production by CDT method. Bla VEB-1 gene was investigated by polymerase chain reaction method. P. aerugionsa 10.2 was used as positive control strain for bla VEB-1 gene.

Forty three isolates (50.5%) were resistant to ceftazidim. Sixty isolates (70.5%) and 15 isolates (17.6%) were resistant to cefotaxime and imipenem, respectively. Seventy nine percent of isolates were ESBL producer. Thirteen point nine percent of the isolates contained bla VEB-1 gene.

Considering high resistance of P. aeruginosa isolates to third and fourth generation cephalosporins, it is necessary to avoid inappropriate use of antibiotics in treatment of ESBL producing organisms.

The aim of the present study was to compare the effects of aerobic exercise, resistance training and combination of aerobic plus resistance training on glycemic control, cardiovascular risk factors, and body composition in patients with type 2 diabetes mellitus (T2DM).

In this interventional study, 152 adults aged 33-69 years with T2DM were recruited from clinic of endocrinology. After a 2-week run-in phase training, 80 subjects were randomly divided into four groups of 20 individuals; aerobic, resistance, combined training, and control groups. Exercise training was performed three times per week for 52 weeks.

Significant reduction in the mean HbA1C was noted in the three training groups. All subjects of the training groups showed improvement in postprandial glucose level, blood pressure, Vo2max, and muscular percentage. Furthermore, the reductions of triglycerides in the aerobic and combined training groups were significant. Also, a significant change was observed in body fat percentage in the resistance and combined groups. Combination of two forms of exercise training led to better enhancement in HbA1C and triglycerides compared with each of the aerobic and resistance groups.

Both aerobic and resistance trainings are effective interventions for management of T2DM complications. However, the combined training is associated with further enhancement in the studied parameters.

Mucormycosis is a highly aggressive fungal infection which has the most aggressive behavior among all fungal infections. This infection typically affects immunocompromised patients and is rare in healthy individuals. Foreign bodies in open injuries may serve as the most common feature of mucormycosis infection in healthy patients. Early diagnosis is essential for successful treatment. Her, we report mucormycosis in a 52-year-old female without any systemic disease, with the history of an extraction of a maxillary first molar for about one month ago. Signs and symptoms included pain in the socket, swelling in maxillary alveolus with diffuse erythema, discharge in the socket, necrotic and exposed bone. In histopathological study, mucormycosis was reported. The patient was treated with debridement, fluconazole, nutritional support and hydration which resulted in patient’s recovery. Foreign bodies like dental calculus and delayed epithelialization in the socket may be considered as the predisposing factors in this case.