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correlation of data

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  • عاطفه شوکتی فر، آرزو علایی*، مسعود رضایی
    سابقه و هدف

    هدف مطالعه بررسی میزان همبستگی بین دو روش اسپیتینگ و تست مدیفیه شیرمر بود. در صورت اثبات همبستگی می توان از روش ساده قابل تکرار، امن و دردسترس فوق توسط کلینیسین ها استفاده کرد.

    روش کار

    مطالعه به روش مقطعی انجام شد. تمامی نمونه ها در ساعت 9 تا 12 صبح بررسی شدند. افراد بزاق خود را در دهان جمع کرده و سپس آن را به مدت پنج دقیقه درون لوله استریل به روش تست اسپیتینگ تف کردند. پس از 30 دقیقه استراحت، طی سه دقیقه با تست مدیفیه شیرمر میزان بزاق غیرتحریکی فرد تعیین شد، ضریب همبستگی اسپیرمن و تست کاپا برای بررسی همبستگی داده ها استفاده شد.

    یافته ها

    تحقیق روی 100 نمونه انجام شد که شامل 40 درصد مرد و 60 درصد خانم و متوسط سن آنها 2 ± 43 سال و 15 درصد نمونه ها مصرف سیگار و 30 درصد افراد مصرف دارو داشتند، ولی هیچ یک از نمونه ها سابقه مصرف الکل نداشت. در روش اسپیتینگ تعداد 36 نفر دارای خشکی دهان و با تست مدیفیه شیرمر 32 نفر خشکی دهان داشتند. تعداد 63 نفر به هر دو روش فاقد خشکی دهان و 31 نفر به هر دو روش دارای خشکی دهان بوده و جمعا 94 درصد همخوانی داشتند. آزمون کاپا نشان داد که میزان همبستگی این دو روش برابر با 96 درصد بود (01/0 > P).

    نتیجه گیری

    به نظر می رسد که همخوانی و همبستگی واضحی بین این دو روش وجود دارد. پیشنهاد می شود تحقیق هایی با کاربرد تست مدیفیه شیرمر در مبتلایان به شوگرن و پرتوتابی سروگردن طراحی شود.

    کلید واژگان: بیماری غدد بزاقی، دهان خشک، سندرم شوگرن، خشکی دهان، همبستگی داده ها
    Atefeh Shokatifar, Arezoo Alaee*, Massoud Rezai
    Background and Aim

    The purpose of the study was to determine the correlation between two salivary estimation methods modified Schirmer test (MST) and spitting method. This could be used in xerostomic patients as a safe, cheap and available methods by clinicians.

    Methods

    The study was done as a cross sectional study. Measurements of unstimulated saliva was conducted  by spitting test, 1 time per subject at 9-12 am for 5 min and mean USFR was calculated by spitting saliva in a sterilized test tube. After resting for 30 min, the saliva estimation was done by Schirmer's Modified Test (MST) method for 3 minutes. The kappa test was used for correlation of data.

    Results

    There were 100 samples, 40% male and 60% female. The mean age was 43 ± 2 years. 15% were smokers and 30% were drug users .No one used alcohol. 36 patients had xerostomia by spitting method and in Schirmer's Modified Test (MST) 32 had dry mouth. By both methods the 63 persons had no dry mouth and 31 persons had xerostomia .The correlation was 94% and 6%, respectively. Kappa test showed that the correlation of data between two methods was 96%. (P > 0.01) Spearman correlation coefficient.

    Conclusion

    It seems that both methods had a correlation with each other. It is proposed to design more studies about Schirmer's Modified Test (MST) application among patients suffering from Sjögren's syndrome or patients whom have been exposed to head and neck radiation.

    Keywords: correlation of data, dry mouth, Sjogren's Syndrome, salivary gland disease, xerostomia
  • Poulomi Mukherjee *, Mousumi Datta
    Background

    Stress is an inevitable and important part of being a medical student. Present study explores perceived stress among undergraduate medical students and the correlation of stress with learning strategies and academic performance.

    Method

    This descriptive cross-sectional study was carried out at Medical College Kolkata, India. The target population was undergraduate medical students from phase II and III. Participants’ learning strategies was measured using the modified Approaches to Learning Medicine (mALM) questionnaire. The stress level of the students was determined by Perceived stress Scale (PSS 10). Academic performance was measured in terms of percentages scored in the last MBBS examination. Data were analysed using SPSS version 21. Frequencies and percentages were calculated for categorical variables and measures of central tendency and dispersion was calculated for continuous variables. Differences of mean were tested by independent samples t-test. Correlation was tested by Pearson correlation test.

    Results

    There were 136 students enrolled in the study; and 129 (94.8%) students scored above 60% in their last MBBS examination. Mean PSS score of the participants was 19.4± 4.17. One hundred and twenty-three (90.4%) students were found to have moderate stress. Deep learning approach was significantly more for MBBS Phase III students (p=0.003). However, perceived stress had no significant correlation with either learning strategy (p=0.916) or academic performance of students (p=0.309).

    Conclusion

    Perceived stress was found to be high among undergraduate medical students in the present study. However, any particular learning style or academic performance was not found to be associated with stress.

    Keywords: Correlation of Data, Learning, Medical education
  • محمدحسین رونقی*
    زمینه

    امید به زندگی، میانگین سال های مورد انتظار سن یک فرد با توجه به آمار مرگ و میر موجود، یکی از شاخص های مهم سلامت شناخته می شود. با توجه به اهمیت این شاخص در سیستم سلامت، بررسی عوامل موثر بر آن مهم است. این مطالعه به بررسی تاثیر فناوری اطلاعات و ارتباطات بر امید به زندگی پرداخته است.

    روش کار

    این مطالعه از حیث روش انجام، یک مطالعه همبستگی بوده که شامل داده های بازه سالانه 2008 - 2018 برای کشورهای خاورمیانه می باشد. داده ها از گزارش های سالانه بانک جهانی و اتحادیه بین المللی ارتباطات راه دور تهیه شدند. تاثیر فناوری اطلاعات و ارتباطات بر امید به زندگی با مدل پنل برآورد شد. همچنین از آزمون Hausman برای بررسی اثرات ثابت و تصادفی استفاده گردید. داده ها با استفاده از نرم افزار Stata نسخه 14 مورد تجزیه و تحلیل قرار گرفت.

    یافته ها

    نتایج این مطالعه تاثیر معنی دار فناوری اطلاعات و ارتباطات بر امید به زندگی در خاورمیانه را تایید کرد. ضریب رگرسیون 0/551 به دست آمد. این مقدار نشان می دهد که وقتی متغیر فناوری اطلاعات یک واحد افزایش می یابد، امید به زندگی 0/551 واحد تغییر می کند. همچنین همبستگی مقطعی 975/0 به دست آمد که این عدد نشان می دهد 97/5 درصد از واریانس به دلیل اختلاف بین پانل ها است.

    نتیجه گیری

    با توجه به تاثیر فناوری اطلاعات و ارتباطات بر امید به زندگی، سیاست گذاران کشورهای خاورمیانه باید استفاده از فناوری اطلاعات و ارتباطات را با برنامه ها و سیستم های موجود ادغام کنند. فناوری به تنهایی یک هدف نیست بلکه صرفا ابزاری برای تقویت سیستم موجود و تحقق اهداف تعیین شده منطقه ای است؛ این امر می تواند به عنوان ابزاری برای دستیابی به سلامت جامعه و توسعه اهداف مرتبط مورد استفاده قرار گیرد.

    کلید واژگان: امید به زندگی، فناوری اطلاعات، خاورمیانه، همبستگی داده
    Mohammad Hossein Ronaghi*
    Background

    Life expectancy is an important health status indicator based on average number of years a person at a given age may be expected to live given current mortality rates. Given this significance, it would be necessary to probe into the factors affecting the life expectancy. Ensuring that information and communication technology (ICT) services are properly used could contribute to development and achievement, as it represents an important issue for the countries moving toward knowledge-based and information-based societies. Therefore, this study explored the impact of the information and communication technology on life expectancy.

    Methods

    This study covers annual data from 2008 to 2018 for a group of countries in the Middle East. Data were retrieved from the Annual Reports such as World Bank and International Telecommunication Union (ITU) data sets. The effects of ICT on life expectancy are estimated with the Panel model. We also used the Hausman test to investigate fixed versus random effects. The data were analyzed by Stata 14 software.

    Results

    The core findings of this study confirm the significant impact of ICT on life expectancy in the Middle East. The calculated Coefficient of the regression was 0.551 indicating how much life expectancy changes when ICT variable increases by one unit. Moreover, the rho (intraclass correlation) was found to be 0.975 showing that 97.5% of the variance is due to differences across panels.

    Conclusion

    Considering the effect of ICT on life expectancy, policymakers of the Middle Eastern countries should integrate the use of ICT with the existing programs and systems. Technology is not an end in itself but merely the means to reinforce the existing system and to meet the locally determined goals. It can be used as a tool to attain broader health and development goals.

    Keywords: Life Expectancy, Information Technology, Middle East, Correlation of Data
  • Ahmad Esmaili Torshabi *, Moslem Ahmadi Arbatan
    Introduction
    One of the most important components in radiotherapy with external surrogates is utilizing consistent correlation model to estimate tumor location as model output on the basis of external markers motion dataset. In this study, imperialist competitive algorithm (ICA) was proposed to process and optimize motion dataset for correlation model. The simplicity of correlation model based on this algorithm may result in less targeting error with the least computational time.
    Material and Methods
    A correlation model based on adaptive neuro-fuzzy inference system (ANFIS) was utilized with database of 20 patients treated with CyberKnife Synchrony system. In order to assess the effect of proposed data optimization algorithm, two strategies were considered. The correlation model was used with and without implementing ICA. Then, targeting error of ANFIS model was compared at two strategies using statistical analysis.
    Results
    The results showed that implementing the proposed algorithm on ANFIS model could remarkably improve the performance accuracy of ANFIS correlation model by eliminating unnecessary and noisy inputs and making the model simpler. Moreover, model simplicity factor could highly reduce model computational time, which is attractive for clinical practice.
    Conclusion
    ICA was proposed as data optimization algorithm on motion dataset of patients treated with external surrogates’ radiotherapy. Our proposed algorithm could highly optimize the input motion dataset of correlation model for estimating tumor position by selecting enough data points with high degree of importance. The final results showed an improvement of targeting accuracy of correlation model, as well as a significant reduction at model computational time.
    Keywords: Targeted radiotherapy, Surrogates, Correlation of Data, optimization
  • Ritin Mohindra*, Utkarash Mishra, Roshan Mathew, Narender Singh Negi
    Introduction

    Globally, stroke is one of the leading causes of deathanddisability-adjusted life-years (DALYs). The red cell distribution width (RDW) is a readily available and inexpensive test which is done routinely as a part of complete blood countin these patients.

    Objective

    In this study, we tried to correlate the RDW with severity of acute ischemic stroke(AIS).

    Methods

    Patients presenting to emergencydepartment (ED)within 24 hours of the onset of clinical signs and symptoms suggestive of AIS were assessed for Glasgow Coma Scale(GCS) and National Institutes of Health Stroke Scale (NIHSS) score followed by non-contrast computed tomography (NCCT) scan. RDW value for all the patients who were included in the study were co-related with the severity of the stroke.

    Results

    The median (IQR) RDW in the patients with minor stroke on the basis of GCS was 13.5 (13.3-13.5), moderate stroke was 13.8 (13.5-14.4) and with severe stroke was 15.4 (15.1-15.6) (p < 0.001). The median (IQR) RDW in the patients with minor stroke on the basis of NIHSS score was 13.4 (13.2 –13.6), moderate stroke was 13.8 (13.5-14.3), and moderate to severe stroke was 14.7 (14.5-15.3) and with severe stroke was 15.5 (15.1-15.7) (p < 0.001). The median RDW in patients who were alive was 13.8 (13.5 -15.1) and in patients who expired was 15.5 (14.5 -15.7) (p = 0.048).

    Conclusion

    Based on the findings of this study,RDWindex has statistically significant correlation with the severity of AIS. So it can potentially be an important parameter to predict the prognosis of AIS patients.

    Keywords: Correlation of Data, Erythrocyte Indices, Severityof Illness Index, Stroke
  • Azimeh Jahanipour, Leila Asadabadi, Mehdi Torabi*, Moghadameh Mirzaee, Elham Jafari
    Introduction

    Electrolyte disorder is a prevalent complication in multiple trauma patients; nevertheless, the role of chloride has been rarely addressed in literature when evaluating serum electrolytes.

    Objective

    The present study was conducted to determine the correlation between serum chloride changes and hospital mortality in multiple trauma patients.

    Method

    The present cross-sectional study measured serum chloride levels in 100 multiple trauma patients upon their admission to the emergency department and 24 hours later. All these patients were followed up in terms of hospital mortality using their medical records. Exact logistic regression was used to measure the effects of independent variables on hospital mortality in the patients.

    Results

    Hospital mortality was found to be 15 (15%), and the mean serum chloride level to be 106.37±4.53 mmol/l upon admission and 112.18±6.16 mmol/l 24 hours later. Although the univariate analysis suggested that serum chloride levels were independently associated with mortality 24 hours after admission (P=0.005), this correlation was insignificant in the multivariate analysis.

    Conclusion

    The present study rejected the hypothesis suggesting the potential role of serum chloride levels in predicting hospital mortality in multiple trauma patients.

    Keywords: Chlorides, Correlation of Data, Hospital Mortality, Multiple Trauma, Serum
  • Azarnoosh M.*, Doostdar H.
    Background

    The importance of continuous monitoring along with rapid and accurate notification of changes in blood components such as hemoglobin concentration, especially in acute situations, encourages researchers to use non-invasive methods for measuring.

    Objective

    This study was aimed to investigate the correlation between hemoglobin concentration and photoplethysmogram (PPG) and the possibility of measuring it by an optical method.

    Material and Methods

    In this applied study, a PPG signal was simultaneously recorded at four different wavelengths for thirty subjects who were referred to the laboratory for a hemoglobin concentration test. After calibrating the special recording probe with a standard pulse oximeter system and applying the required preprocessing on the obtained signals, the peak-to-peak value of PPG signals was extracted. Finally, the correlation between the peak-to-peak value of the signal at a certain wavelength and hemoglobin concentration was analyzed using Spearman and Pearson correlation for determining the process of changes in the data.

    Results

    The results demonstrated that based on the normal distribution of data at 590 nm wavelength, there is a significantly negative correlation between a function of the signal peak slope and the hemoglobin concentration, with a Pearson coefficient of -0.787 (p<0.01). In addition, the investigation of rank correlation indicated a significantly negative correlation of -0.842 (p<0.01) using Spearman correlation analysis.

    Conclusion

    Considering the high correlation between hemoglobin concentration and PPG signal characteristics, optical methods can be used to develop a rapid, precise, clean and inexpensive method to measure hemoglobin concentration.

    Keywords: Hematologic Tests, Hemoglobinometry, Photoplethysmography, Correlation of Data
  • Reza Nikfarjam, Zahra Khazaeipour, Alireza Baratloo, Seyed Mojtaba Aghili*
    Background

    All the trauma scoring systems (TSSs) have some limitations, and none is useful for patient monitoring. Recently, investigators have tried to modify the TSSs to improve their use.

    Aims

    This study was conducted to determine whether any correlation exists between dysoxia metabolism markers (DMMs), including venous base deficit (BD) and HCO3 level with different TSSs.

    Materials and Methods

    In this cross‑sectional study, all multiple trauma patients admitted to the emergency department were eligible. Blood samples for venous blood gas analysis were taken at the onset of resuscitation process. TSSs, including trauma index (TI), abbreviated injury score (AIS), Injury Severity Score (ISS), Revised Trauma Score (RTS), and Trauma Score‑ISS (TRISS), were calculated for the patients. Spearman’s rank correlation coefficient test was applied to find the association between the independent variables.

    Results

    A total of 285 patients with a mean age of 33.37 ± 15.29 fulfilled the inclusion criteria, of which, 211 cases (74.0%) were male. Statistical analysis revealed that there was a correlation between TI and HCO3 level (P = 0.0001, r = −0.37) and also TI and BD (P = 0.0001, r = −0.47). Furthermore, there was an indirect correlation between AIS and ISS with HCO3 and BD levels and the direct correlation between RTS and TRISS with HCO3 and BD levels.

    Conclusion

    It is likely that there is a statistical correlation, although weak, between TSSs with DMMs, including HCO3 and BD level.

    Keywords: Acid‑base imbalance, correlation of data, hemodynamic monitoring, trauma severity indices
  • Payman Moharamzadeh, Farzad Rahmani, Shirin Foroughifar, Kavous Shahsavarinia *
    Introduction
    Early diagnosis of pulmonary thromboembolism (PTE) is crucial in clinical medicine. Many para-clinical measurements are used to diagnose PTE.
    Objective
    The present study was conducted to evaluate platelet indices in terms of diagnosing PTE.
    Methods
    The present case-control study was conducted between September 2015 and September 2016 with 173 patients suspected of PTE in the emergency wards of Shahid Madani Hospital and Imam Reza Hospital affiliated to Tabriz University of Medical Sciences, Iran. The patients’ platelet indices were checked upon admission and they were evaluated in terms of diagnosing PTE. Platelet indices included mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PL-CR). PTE was diagnosed in 125 out of the 173 patients. Platelet indices were also compared between two groups.
    Results
    No statistically significant differences were observed between the two groups in term of demographic variables (P>0.05). MPV was found to be 10.38±8.59 in the case group and 9.46±1.11 in the controls (P˃0.05). PDW was also found to be 12.86±5.57 in the case group and 12.32±2.48 in the controls (P>0.05). Moreover, PL-CR was found to be 22.59±7.32 in the case group and 21.97±8.16 in the controls (P>0.05).
    Conclusion
    According to the obtained results, platelet indices do not increase in PTE. They cannot be therefore used to diagnose PTE in suspected patients.
    Keywords: Blood Platelets, Correlation of Data, Diagnosis, Pulmonary Embolism
  • Reza Rostami, Vahid Sadeghi, Jamileh Zarei, Parvaneh Haddadi, Saman Mohazzab Torabi, Payman Salamati
    Objective
    The aim of this study was to compare the Persian version of the wechsler intelligence scale for children - fourth edition (WISC-IV) and cognitive assessment system (CAS) tests, to determine the correlation between their scales and to evaluate the probable concurrent validity of these tests in patients with learning disorders.
    Methods
    One-hundered-sixty-two children with learning disorder who were presented at Atieh Comprehensive Psychiatry Center were selected in a consecutive non-randomized order. All of the patients were assessed based on WISC-IV and CAS scores questionnaires. Pearson correlation coefficient was used to analyze the correlation between the data and to assess the concurrent validity of the two tests. Linear regression was used for statistical modeling. The type one error was considered 5% in maximum.
    Findings
    There was a strong correlation between total score of WISC-IV test and total score of CAS test in the patients (r=0.75, P<0.001). The correlations among the other scales were mostly high and all of them were statistically significant (P<0.001). A linear regression model was obtained (α=0.51, β=0.81 and P<0.001).
    Conclusion
    There is an acceptable correlation between the WISC-IV scales and CAS test in children with learning disorders. A concurrent validity is established between the two tests and their scales.
    Keywords: Correlation of Data, Learning Disorders, Wechsler Scales, Intelligence Test, Cognitive Assessment
  • حسین تقی زاد، علیرضا مهری دهنوی*، مجید محمد بیگی
    مقدمه

    با شناخته شدن توالی ژنوم های مختلف، گام منطقی بعدی یافتن عملکرد و تنظیم آن ها می باشد. جهت دسته بندی ژن ها در آزمایشگاه مواردی همچون توصیف رفتار ژن، عوامل کنترل کننده ی بیان ژن و تعامل پروتئین بررسی می شوند. انتظار می رود ژن هایی که با مکانیسم مشابهی تنظیم می شوند، دارای الگوی بیان یکسانی باشند.

    روش ها

    در این مقاله، یک روش خاص خوشه بندی به نام بایکلاسترینگ را برای داده های میکروآرایه به دست آمده از بیماران مبتلا به MS (Multiple sclerosis) معرفی می کنیم. از دیدگاه بیولوژیکی، بایکلاسترهای تنظیم کننده ی ژنی شامل ژن هایی است که در چندین نقطه از زمان تحت چندین شرایط رفتار مشابهی دارند. با شناسایی این بایکلاسترها، پی بردن به مکانیسم های تنظیمی که باعث این رفتار مشترک می شوند ممکن می شود.

    یافته ها

    ما از فرمت تغییریافته ی الگوریتم ISA (Iterative signature algorithm) برای استخراج پروفایل های هم بیان ژن از داده های میکروآرایه استفاده کردیم. روش KNN (K-nearest neighbor) در ترکیب با ISA، الگوریتمی ارائه کرد که منجر به یک روش مطلوب برای به دست آوردن مجموعه ی همبسته ای از ژن های همسان در داده های میکروآرایه شد.

    نتیجه گیری

    این الگوریتم بر روی دو نوع داده ی سنتز شده و داده ی واقعی (اطلاعات بیماران مبتلا به مولتیپل اسکلروز) اعمال شد و نشان داد که تفاوت بارزی بین بایکلاسترهای استخراج شده در مقایسه با ISA وجود دارد؛ هر چند که بهره وری این روش بر روی داده ی سنتز شده و داده ی مبتلایان به مولتیل اسکلروز نشان داده شد، اما برای هر نوع داده ی دیگری نیز قابل استفاده خواهد بود.

    کلید واژگان: میکروآرایه، بایکلاستر، سری های زمانی، همبستگی
    Hossein Taghizad, Alireza Mehridehnavi, Majid Mohammadbeigi
    Background

    After recognition of sequences of different genomes, the next logical step is the discovery of their function and regulation. To classify genes in the laboratory, factors such as the behavior of genes, gene expression control and protein interactions have been reviewed. It is expected that genes with similar regulation mechanisms have the same expression patterns.

    Methods

    In this paper, we introduce a special way of clustering, called biclustering, for microarray data obtained from multiple sclerosis (MS) patients. From a biological perspective, gene regulatory modules consist of genes that have similar behaviors at different points of time under several conditions. By identifying these modules, the recognition of the regulatory mechanisms that are the common causes of genes behaviors might be conceivable.

    Findings

    We used a modified format of iterative signature algorithm (ISA) to extract co-expressed gene profiles from microarray data. The combination of K-nearest neighbor (KNN) algorithm and ISA provides a helpful algorithm which results in an outstanding and optimum way to obtain similar genes in microarray data.

    Conclusion

    The algorithm was performed on a synthetic as well as a real database (MS patients’ data), and showed a pronounced difference between the extracted modules in contrast to ISA. Although we showed our method’s efficiency over synthetic and MS data, it will be usable for any other kinds of data. In other words, our method is based on a series of logical and statistical methods rather than data-based methods.

    Keywords: Microarray, Biclustering, Time series analysis, Correlation of data
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