Effect of swimming training and Fenugreek seed extract on plasma glucose and antioxidant activity in heart tissue of streptozotocine - induced diabetic rats
Author(s):
Abstract:
Background And Objective
Free radical production andsubsqunt oxidative steress can be due to hyperglycemia and its oxidation. This study was done to evaluate the effect of swimming training test and Fenugreek seed extract on plasma glucose and antioxidant activity in heart tissue of streptozotocine – induced diabetic rats. Methods
In this experimental study, 50 male wistar rats were allocated into five groups; diabetic (DC, n=10), healthy control (HC, n=10), swimming training (S, n=10), swimming training + Fenugreek seed extract (1.74 g/kg/bw) (SF1, n=10), and swimming training + Fenugreek seed extract (0.87 g/kg/bw) (SF2, n=10). Streptozotocine (60 mg/kg/bw) was used for induction of diabetes in DC, S, SF1 and SF2 groups. Serum glucose and the rat heart tissue antioxidant enzymes activities of superoxide dismutase, Catalase and Glutation peroxidase were determined. Results
Body weight in all groups were significantly reduced in comparsion with healthy control group (P<0.05). Plasma glucose level significantly reduced in SF1 and HC groups compared to diabetic group (P<0.05). Cardiac antioxidant enzymes in swimming training, SF1 and SF2 groups significantly increased in compare to diabetic group (P<0.05). Conclusion
The combination of endurance swimming training and fenugreek seed extract can reduce plasma glucose and increase cardiac antioxidant enzymes in streptozotocine – induced diabetic rats.Keywords:
Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:16 Issue: 2, 2014
Pages:
29 to 36
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