Perinatal and neonatal effects of rhizome extract of ginger on levels of insulin and ALT, AST, ALP on adult children of first-generation female rats
Message:
Abstract:
Background and Objectives
In the world rhizome of ginger is used as a food flavoring and in the treatment of many diseases including diabetes. Considering the prevalence of diabetes during pregnancy and cost of chemical drugs that is used in treating the disorder, especially during pregnancy and lactation and their side effects on children, this study aimed to investigate the effect of neonatal and perinatal extract of ginger on insulin levels and enzymes ALT, AST, ALP in offspring of adult rats.
Material and Methods
This experimental study was conducted on 72 adult female rats. The rats were divided into 9 groups (N=8)including; perinatal, neonatal control and 6 experimental groups receiving doses of 50,100 mg / kg 200 mg / kg alcoholic extract of ginger(orally). At the end of the experiments, blood was collected from heart, and the isolated serum from samples was analyzed for the insulin levels and ALT, AST, ALP enzymes. Data were analyzed by using ANOVA and Duncan tests.
Results
The results showed that ginger rhizome extract causes significant increase in levels of insulin and significant dose-dependent decrease in ALT, AST, ALP enzymes on male and female offspring.
Conclusion
Ginger with compounds, Jinjerols, Sezkuinterpens, selenium, flavonoids and antioxidants and anti-inflammatory stimuli, serotonin secretion and reduce blood glucose has significant effects on insulin levels and enzymes ALT, AST, ALP.
Language:
Persian
Published:
Journal of North Khorasan University of Medical Sciences, Volume:7 Issue:2, 2015
Pages:
299 - 307
magiran.com/p1449225  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!