Effect of two aerobic exercise on levels of apelin and its receptor in the old rats heart tissue with chronic kidney disease

Chronic kidney disease as an important risk factor associated with some disorders including hypertension and heart failure which is the major cause of death and disability in older people. Hence, the aim of the present study was to investigate the effects of two types aerobic exercise on levels of apelin and its receptor in the old rats heart tissue with chronic kidney disease
Methods and Materials: In this experimental study, 28 aged male wistar rats )48 to 50 weeks) were selected and randomly divided into 4 groups: control, doxorubicin, doxorubicin-30minutes training and doxorubicin-60 minutes training. Chronic kidney disease induced by a single subcutaneous injection of doxorubicin (8.5 mg kg). The swimming training program includes 3 times per week, 30 and 60 minutes for 8 weeks. The levels of apelin and its receptor in heart tissue measured by using ELISA method. one-way analysis of variance was used to analyze the data)p