The effect of six weeks of increasing endurance training and consumption of L-carnitine on BAX / BCL-2 and oxidative stress indices in the heart tissue of diabetic rats

Diabetes is one of the serious medical problems in recent years. The purpose of this study was to investigate the effect of six weeks’ endurance training and L-carnitine consumption on Bax / Bcl-2 and oxidative stress indices of heart tissue of diabetic rats.

In this experimental study, 45 male Wistar rats (weighing 20 ± 250 gr) were randomly divided into 6 groups including healthy control, diabetic control, sham, exercise, L carnitine and exercise and L-carnitine. Rats were diabetic peritoneally injected with nicotinamide at a dose of 95 mg / kg body weight and after 15 minutes of STZ injection of 55 mg / kg body weight. Rats receiving El Carnitine received daily 100 mg of l-carnitine orally. Aerobic exercises were performed for 5 weeks a week, from 9:00 to 11:00, for six weeks. The variables were measured by ELISA and ASA kits and in the heart tissue. One-way ANOVA and Tukey's post hoc test were used to analyze the data using Shapiro Wylak test.

The results showed that increasing endurance training and L-carnitine consumption had a significant effect on GPX (P = 0.001), MDA (P = 0.001), and Bax / Bcl2 heart rate (P = 0.001) in diabetic rats.

According to the findings of this study, the use of aerobic exercise and L-carnitine (in consultation with the physician) are recommended to reduce the complications of diabetes.