The change in mitral valve prolapse after atrial septal defect closure procedure

Congenital heart disease could have effect on life expectancy and may be associated with other anomalies causing hemodynamic abnormality which regress after resolving the shunt. The purpose of this study was to investigate the change in the mitral valve prolapse after defect closure in patients with atrial septal defect. Methods & Materials: This study including all patients with atrial septal defect (ASD) who referred to Ghaem and Imam Reza Hospital in Mashhad from September 2017 to September 2018, and had been candidates for atrial septal defect closure. Demographic data were collected. Two-dimensional echocardiography was done before and after defect closure procedure. Exclusion criteria including patients with suboptimal echocardiography view and post procedure residual shunt.

The results of this study showed in patients with atrial septal defect, the prevalence of mitral valve prolapse was 51.2%. Also, 19.05% of patients with mitral valve prolapse before the defect closure procedure, did not have any prolapse after the procedure. On the other hand, the mean and standard deviation of right ventricle and right atrium size and pulmonary artery pressure after the procedure were significantly lower than values before the procedure.

The results of this study indicated, in the presence of ASD, right ventricular (RV) volume overload by effect on left ventricle, could cause mitral valve structural abnormality. This abnormality could be regress after ASD closure and resolving of shunt effect on RV.