Evaluation of serum homocysteine levels with coronary artery disease in angiographic patients
Article Type:
Research/Original Article (دارای رتبه معتبر)

Cardiovascular disease is estimated the cause of 17.3 million deaths annually in the world and 27.4% of deaths in Iran. Since the common risk factors cannot currently predict all causes of cardiovascular disease, researchers have suggested that other factors such as oxidative stress, trace elements, inflammation, and homocysteine may be potential contributors to cardiovascular disease. Therefore, in this study, we assess the association of serum level of homocysteine with the severity of coronary artery involvement.

Material and Methods

In this cross-sectional study, 347 patients referred to Ghaem Hospital for angiography and 103 healthy individuals without cardiac symptoms were evaluated. Subjects were divided into five groups with more than 50% stenosis of one (1), two (2), and three (3) arteries, individuals with normal angiography or less than 50% involvement (4), and healthy subjects (5). Serum homocysteine level was measured by ELISA at Bou-ali Research Institute. Statistical data analysis was performed using SPSS software version 21.


In this research, 106 healthy people, 91 normal people, and 80, 87, and 89 people with stenosis in one, two, and three arteries, respectively were studied. The mean homocysteine in the groups with stenosis of one, two, and three vessels was significantly higher than the normal and healthy groups (P <0.001). The results of logistic regression analysis showed that increment of one unit of homocysteine raised the chance of vascular involvement in people with one, two, and three-vessel involvement into 1.235 (1. 053-1. 273), 1.289 (1.125-1.414), 1.461 (1.326-1.611), respectively (P <0.001)


The results of the present study showed that increase in concentration of homocysteine as an independent risk factor can lead to greater prevalence and progression of vascular stenosis.

Medical Journal of Mashhad University of Medical Sciences, Volume:64 Issue: 2, 2021
2723 to 2733
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