PREDICTIVE VALUE OF PLATELET MARKERS IN THE PATIENTS WITH ACUTE PULMONARY THROMBOEMBOLISM

Due to the role of platelets in thrombosis formation, platelet activation markers may be able to predict the prognosis in patients with acute pulmonary thromboembolism.

In this prospective cohort study, 40 patients were evaluated for platelet parameters including mean platelet volume (MPV) and platelet distribution width (PDW) as well as for pulmonary embolism severity index (PESI) risk score. The primary goal was to evaluate the relationship of these parameters with all-cause mortality in the studied hospital.

Out of 40 patients, 13 (32.5%) were male and 27 (67.5%) were female. The patients were classified based on the median PESI into two groups of ≥100 (47.5%) and <100 (52.5%) and then were analyzed. 25 patients (62.5%) had known risk factors for PTE. 26 patients (65%) had no bad outcome and 14 patients (35%) had bad outcome. The mean MPV and PDW were about 35 and 18 in the ≥100 group and about 91 and 26 in the <100 group, respectively.

There was no significant relationship between platelet indices with prognosis and severity of PTE. Evaluation of the relationship between platelet indices and pulmonary thromboembolism severity score using Pearson correlation coefficient (Spearman) test showed that MPV was inversely related to embolism severity (r = - 0.16), although this difference was not statistically significant (p<0.05). PDW index was directly related to the severity of embolism (r = 0.08).