Comparing the effect of ketorolac and Gelofen on postoperative pain after third molar surgery: a randomized clinical trial

Management of pain and inflammation after third molar surgery is an important challenge of this treatment. Various medications have been proposed for pain control after surgery. Comparing the effectiveness of various drugs used in this field can improve dentists' clinical decisions. The aim of this study was to compare the effect of Ketorolac and Gelofen on pain relief in patients undergoing third molar surgery.

This randomized single-blinded clinical trial was performed on 140 patients who were divided into two groups of 70 after receiving the ethical code. The first group was prescribed 400 mg Gelofen capsule for 1 week, while the second group was prescribed 30 mg ketorolac ampule for 1 week. Then, using the visual analog scale (VAS), the patient’s pain was recorded 48 hours, 1 week, and 2 weeks after surgery. Data analysis was carried out using SPSS20 software by descriptive analysis of the results. Ki-square, T-test, and variance analysis were also used for analysis of variables.

The pain level in the ketorolac group after 48 hours, 1 week, and 2 weeks following surgery was significantly less than Gelofen group (P<0.01). Ketorolac effect on pain was irrelevant to the gender, age, and type of tooth variables.

From the results, it was concluded that Ketorolac had greater effect on pain relief after third molar surgery than Gelofen.