The Effect of Low Laser Therapy on GCF level of PGE2 During Orthodontic Treatment

 PGE2 plays a very important role in the mediation of orthodontic therapies and dental reactions. Laser therapy in dentistry can be used to reduce pain, increase genetic bone, stimulate teeth, and reduce localized pain in time periods. The purpose of this study was to determine the effect of low-power laser therapy on the surface of PGE2  gingival fluid during orthodontic treatment.

 In this double blind clinical trial study, 15 patients with crowning or protrusion of teeth requiring constant orthodontic treatment, along with pulling of the first two right and left prime mules, and then retracting the anterior teeth, were selected. After the first periodontal period examinations was performed in patients undergoing orthodontic treatment. One quadrant was selected as the experimental group and the opposite quadrant was selected as the control group. In the experimental group, low power diode laser irradiation was performed along the entire length of the gingival groove on days 0 (start of treatment), 2, 18 and 30 (total 4 days) after orthodontic treatment and sampling. The samples were transferred to the laboratory and determined at PGE2 level using an ELISAR device. Data were analyzed by Repeated Measure test, Friedman test and paired t-test.

 The mean the PGE2 fluid in the orthodontic treated teeth, In the days of treatment, 30,18,2 laser radiation was significantly different between the experimental and control groups (P <0.001). In laser therapy, with significant increase in time, there was a significant reduction in PGE2 (p<0.05).

 Regarding the effect of reducing the pain of using and not using the laser in orthodontic movement, adjuvant treatment with low power laser reduces PGE2 as a mediator causing pain