مجله دانشگاه علوم پزشکی سبزوار
سال بیست و هفتم شماره 4 (پیاپی 111، مهر و آبان 1399)

Brain-Behavioral Systems contribute to the development of wide variety of emotional disorders, including anxiety and depression.  The aim of this study was to compare the Brain- Behavioral Systems in patients with anxiety, patients with depression, and healthy individuals.

This study was a cross-sectional study in which 45 individuals with anxiety (moderate to high score in Beck Anxiety Inventory (BAI) and low score in BDI-II) and 45 individuals with depression (moderate to high score in Beck Depression Inventory-II (BDI-II) and low score in BAI) who referred to private and public health centers in Jiroft were selected through purposive sampling and matched with 45 healthy individuals (low score in BDI-II and BAI) for age and gender. After informed consent, participants were asked to fill the questionnaires including  Jackson-5 Scale, 2nd version of Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI) and were allocated to different groups based on the score of the questionnaires. Data were analyzed using one-way analysis of variance by spss21 software.

Result showed that there were significant differences between three groups in Behavior Inhibition System, Fight, Flight and Freeze. Also, the differences were not significant in Behavioral Activation System.

Given the different functions of the Brain -Behavioral Systems in patients with anxiety, patients with depression, and healthy individuals, this theory may explain the etiology of anxiety and depression.

Non-steroid anti-inflammatory drugs (NSAIDs) are a widely used self-medication group among different classes of communities, including university students. Therefore this study is conducted to determine the rate of NSAIDs self-medication among student in khalkhal in 1396.

This was a Descriptive-analytical study, conducted on 400 university students who selected randomly from medical sciences, azad and payame noor universities in khalkhal city. Data were collected by demographic and self-medication questionnaire then, the obtained data analyzed by descriptive and inferential statistics (chi- square) at a significant level, p <0.005 by SPSS software (V.18).

The rate of self-medication with NSAIDs was 73.6% among university students. The most used medicine were Jelofen (47.7%) and ibuprofen (44%). The major underlying condition motivating NSAIDs sought were dysmenorrhea (46.7%), headache (42.8%). More than half (57.8%) use NSAIDs without any specific pattern and (38.6%) selfmedicated by their own Initiative 74.2% knows herbal medicines and their benefits and (93.5%) agree to use herbal medicines instead of chemical.

The findings of this study showed a high prevalence of selfmedication among university students. Considering the complications caused by this phenomenon, it is suggested Teaching students with the goals of modifying drug-related behaviors and discounting the complications of arbitrary and self-medication costs should be addressed to the authorities in advance.

In recent years, the uses of chemical pesticides in agricultural crops more than the world standards. The aim of this study was evaluate the knowledge, attitude and practice of farmers in Jovuin on the environmental health aspects of pesticide use in the 2018 years.

This is a cross-sectional study. The population of this study is farmers of Jouvin of Khorasan Razavi province. The sample size for study was 100 farmers. The data obtained with a standard questionnaire and data analysis was performed using SPSS version 20 software.

The knowledge, attitude and practice of farmers in relation to environmental health and safety principles during spraying indicate that the average score was 12.43 in attitude and awareness, but the very low mean score of individuals (5.46) in the performance. Also Pearson analysis showed the have scientific relation with attitude and awareness. (P-Value>0.05)

The practice of farmers in this study has received a very low score. This subject requires the scientific and practical training of farmers so that they can be used to reduce the amount of toxins consumed and thus reduce the pollution of the environment

Emerging infections have a great impact on the health of pregnant mothers and their fetuses. Due to the importance of contracting this virus during pregnancy and due to the emergence of this virus and the limited number of studies on the consequences of contracting this disease during pregnancy, this review study aims to summarize the reported studies on covid-19 infection. Performed during pregnancy and childbirth.

In this study, a review of all studies conducted in English on covd-19 in pregnancy and childbirth from 2019 to March 2020, in the databases Scopus, Google Scholar, Pubmed, Science Direct, Cochrane, and keywords covid-19, sars-cov-2, coronavirus-2019, 2019-ncov, pregnancy, delivery.

In these studies, a total of 103 pregnant mothers with covid-19 and their maternal and neonatal outcome and the incidence of infants of mothers with covid-19 were studied. Most of the studies reported in different cities of China were. Pregnant mothers have been examined.

Based on the reported findings, vertical transmission of mother to fetus has not been reported so far and maternal and neonatal outcome have been reported in all well-studied studies, all samples of amniotic fluid, placenta, breast milk and vaginal discharge samples based on studies. COVID-19 was negative and no maternal deaths were reported at the time of this study. Currently, due to the lack of effective treatment and vaccines, the best way to deal with this disease is to avoid infection and prevent its spread through protective measures and personal hygiene.

Selective muscle strengthening of quadriceps synergistic muscles is important to improve muscle performance specially to prevent Patella- femoral syndrome. Therefore, the aim of this study was to investigate the pattern of the Vastus medialis and Vastus lateralis activity in response to the intensities of super maximal eccentric and submaximal concentric contractions.

12 healthy men students randomly selected (21±2 years, 173±12 cm, and 71±8 kg) from University of Bojnord.  Electromyography activity of quadriceps muscles was measured during contraction by using electromyography system. To evaluate the date, the Multivariate variance (MANOVA) and post hoc test (TUCKY) were applied at p˂0.05.

The data analysis was demonstrated the electromyography activity of Vastus medialis and Vastus lateralis were significantly increased with an increased work load during the eccentric contraction rather than concentric contraction which suggests that progressive resistance training using super maximal eccentric contraction is more effective than submaximal concentric contraction to create the neuromuscular adaptations.

Furthermore, it was observed a significant interaction between muscle type and contraction intensity for muscle electromyography activity. Since, during the submaximal contraction, the EMG activity of Vastus medialis was significantly higher than Vastus lateralis, while it was not the case during super maximal contraction, which could indicate the possibility of selective muscle strengthening of Vastus medialis in sub-maximal intensity to prevent patella-femoral syndrome.

Due to the increasing number of aging population in developing countries such as Iran and the role of social capital and successful aging in the aging population, this study aimed to investigate the relationship between social capital and successful aging in the aging population, Iran.

This cross-sectional descriptive study was performed on 402 aging people randomly selected from 6 health centers in the city, 2 aging homes and 3 open centers (medical sciences, education, social security) in 2019-2020 as a research population by stratified sampling. To collect information from the aging demographic information questionnaires, Onyx and Bowen Social Capital Questionnaire, Successful Aging Questionnaire, and aging Cognitive Status Questionnaire (AMT) were used for data collection. Data were analyzed using SPSS-22 software and Pearson correlation, focal tests, and multivariate regression.

The mean of age of the subjects were 68.8 years. The social capital score was correlated with the successful aging, which was positively and moderately correlated (r = 0.662). Nearly 30% of the changes in the scores of the dependent variable of successful aging were influenced by the variables of social capital and marital status, living with relatives, employment, and educational level (r2 =  0.29).

The results of this study confirming the predictive power and impact of social capital on the index of successful elderly in the community are puzzling and relationship was found to be more significant. Social capital as an independent variable significantly affects successful aging as a dependent variable.in other words, social capital has the ability to predict successful aging.in some aspects including physical health, mental health, physical function and cognitive status. This findings could be a good guide for further research focus and for the authorities and practitioners, to achieve successful aging goals.

Green synthesis of silver nanoparticles is a simple and low-cost method. In addition, finding new therapeutic effects for silver nanoparticles is considered as an attractive field in cancer research. In the present study, synthesis of silver nanoparticles was performed by aqueous leaf extract of barberry. The effects of Ag nanoparticles were evaluated on cell viability and expression levels of ODC1 gene of the human breast cancer cell line (MDA-MB-231).

The synthetic nanoparticles were analyzed by UV-vis spectrophotometry and Transmission Electron Microscopy. The cultured cancer cells were treated under different concentrations of synthesized nanoparticles.The viability of the cells was analyzed by MTT assay and relative expression of ODC1 gene by Real-Time PCR.

TEM photomicrographs showed that the spherical silver nanoparticles have been synthesized with an average size of 16 nm. The results showed cytotoxicity of silver nanoparticles in a time and dose-dependent manner. The average IC50 calculated was 16.48 µg/ml.  The results also showed that silver nanoparticles decreased ODC1 gene expression levels about 4 folds at 20 µg/ml nanoparticles compared to control.

It seems that green synthesized silver nanoparticles through the gradual release of silver ions in the acidic environment of the cancer cells and production of oxygen radicals, as well as reduction of ODC1gene expression cause diminish of cancer cell viability.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with an unknown etiology. The disease affects several organs such as central nervous system. The purpose of this study was to assess memory profile (working, visual and auditory) in SLE patients and healthy individuals.

Thirty SLE patients and 30 healthy individuals were selected by the convenience sampling method. The sample was evaluated by Letter-Number Sequencing Test, Rey auditory verbal learning test (RAVLT) and Visual Memory test (Wechsler Memory III subscale). Data were analyzed by the univariate analysis of variance, multivariate analysis of variance and the  Mann- Whitney U Tests.

The results revealed a significant difference (p<0/005) between the two groups in  working memory. There were no significant differences between SLE patients and healthy individuals in terms of immediate auditory memory and immediate visual memory. The results showed the significant differences between two groups in delayed visual memory (free recall and recognition) (p<0/02) and delayed auditory memory (free recall and recognition) (p<0/04).

Memory of  patients diagnosed with Systemic Lupus Erythematosus, especially working, visual and auditory memory dimensions was be  affected by neurological deficits related to the illness, which makes early neuropsychological assessments and related rehabilitation programs even more vital.

Metabolic syndrome is known as a risk factor for dementia and various degrees of cognitive impairment. The aim of this study was to Comparative study of diagnostic value of Montreal cognitive assessment (MoCA) and Mini–Mental state examination (MMSE) tests for assessment and cognitive impairments screening in patients with metabolic syndrome.

This descriptive-analytical study was performed on 107 patients with metabolic syndrome. Cognitive impairment was examined by MoCA and MMSE tests.  Data were analyzed by SPSS 18 software.

Mean score of MMSE and MoCa tests were 23.28 ± 2.66 and 22.06 ± 2.93, respectively. 84 patients (78.5%) had a MoCA test impairment (cognitive impairment). Based on the MMSE test, 66 patients (61.68%) had cognitive impairment. The sensitivity and specificity of the MMSE test were 73.81% and 82.61% respectively. MMSE diagnostic test with age (p=0.000, CC= -0.459), BMI (p = 0.000, CC = -0.338), FBS (p = 0.000, CC=-0.51), the levels of triglyceride (TG) (p = 0.000, CC = -0.56) and HDL (p = 0.000, CC = -0.54) were significantly correlated.

Cognitive impairment is noticeable in patients with metabolic syndrome and it seems that metabolic syndrome markers such as fasting blood glucose, triglyceride levelsand ets associated with cognitive impairment in these patients. MMSE test is a desirable sensitivity and specificity in evaluating cognitive impairment in patients with metabolic syndrome. However, because of the lack of studies in this field, are recommended for more comprehensive conclusions.

Anxiety affects learning. It causes of many physical, and psychological problems. No qualitative study was seen in this matter.Therefore, the purpose of this study was to explain the students' experiences about the test anxiety and the anxious factors associated to the teacher.

This was a qualitative content analysis study, which was conducted in 2016. Participants were 25 students from Sabzevar University of Medical Sciences who had at least two semesters of study and participated in the final exam. The sampling method was initially goal oriented. The data were collected using a semi-structured interview with a presence in the field. Data analysis was carried out using conventional content analysis.

5 main categories and 14 sub-categories explored that main categories including the consequences and complication of test anxiety, teacher's teaching and evaluation strategy, teacher - student interaction strategy, the supportive role of teacher at the exam session, and learning self-management and control of anxiety were extracted from the data.

Using methods such as relaxation and resorting, the more recognition of teachers, the use of young faculty members from the experience of skilful teachers, the use of new educational methods, identifying sufficient references and asking questions from the same references, teacher’s attending in test session from the first to the end of the exam, and distributing the grade score during the term, are of the factors that can reduce student anxiety.

Exercise trainings have beneficial effects on myocardium by changing the concentration of growth factors and their receptors and reduces the risk of heart failure. The aim of this study was to determine the effect of an Eight-week resistance training on ActRIIβin the myocardial left ventricular and plasma levels of GDF11, GDF8 in old male rats.

After the familiarization period, fourteen old male rats with age range 24 to 27 months were randomly divided into control (n= Seven) and training (n= Seven) groups. Resistance training was included eight weeks and five sessions per week climbing from a 1-meter ladder. GDF11 and GDF8 were measured by ELISA method and ActRIIβin the myocardial left ventricular was measurement by IHC method. Independent t-test was applied for statistical analysis of the data (p≤0.05).

Comparisons between groups showed a significant difference between the training and control groups in GDF11 (p≤0.001), GDF8/GDF11 (p≤0.001), GDF8 (p≤0.027) and heart weight (p≤0.031). Between groups comparisons not showed a significant difference between the training and control groups in myocardium ActRIIβ (p>0.05).

It seems that resistance training is effective in Seniors cardiac physiological hypertrophy with beneficial effects on growth factors. Therefore, these trainings can be used to reduce the incidence of heart failure; however, more studies are needed in this regard.

Epilepsy is a chronic and multifactorial disease characterized by sudden and repeated seizures. Carbamazepine is the most common medicine for treating epilepsy. Today, the use of LFS as an alternative treatment is considered in patients resistant to drugs. Therefore, in this research, the effects of LFS and carbamazepine on epilepsy in dorsal hippocampus by using Kindling method on the seizure indices have been compared  in adult male rats.

In this study, 50 adult male rats were randomly divided into 5 groups: Kindle (KND), KLFS, MCK, CBZ20K and CBZ40K. Kindle's group received a daily stimulant of Kindling in a fast way, in the CA1 region of the dorsal hippocampus. In other groups, daily Kindling stimuli, similar to the Kindle group, were applied. In the Kindle + LFS (KLFS) group, LFS stimuli were immediately triggered after the kindling. In methylcellulose + kindling (MCK) group, before stimulation, the amount was 0.2ml solution of methylcellulose 0.5%  was given intraperitoneally. Drug + Kindling (CBZ20K and CBZ40K) groups received intraperitoneal carbamazepine 20mg / kg or 40mg / kg, respectively, before receiving kindling stimuli.

Findings from this study indicate that the use of LFS or carbamazepine significantly reduced the mean seizure severity, total seizure duration, and the duration of afterdischarge in the KLFS and CBZ40K groups compared to the KND group (p <0.05). The important point is that the effective dose of CBZ has a more reduced effect on seizure indices than LFS.

Regarding the results, it seems that, the effective dose of CBZ to be more effective than LFS  stimulation following the hippocampal kindling in reducing seizure indices.

Effective relationship between couples is the most important part in family good function. The purpose of this study was to compare the effectiveness of education on the effect of communication skills training and cognitive-behavioral therapy on marital satisfaction and happiness of couples with sexual desire disorders.

The research was carried out using a semi-experimental design with a post-test, pre-test, and control group design in the first 6 months of 2016. Among the patients referred to the reproductive health centers of Tehran, 60 couples who had at least one DSM-V criteria had sexual dysfunction, were selected and randomly assigned to three groups of communication skills training and cognitive-behavioral therapy and control. The instrument was the Oxford Happiness Inventory and Enrique Marital Satisfaction Questionnaire. The covariance analysis and bin porridge correction were used to analyze the data.

The results showed that communication skills training and cognitive behavioral therapy could significantly increase marital satisfaction and happiness (p>0.05) and there were no statistically significant differences between communication skills training and  cognitive  behavioral therapy in increasing marital satisfaction and happiness.

It can be concluded that using communication skills and cognitive-behavioral therapy can increase the happiness and marital satisfaction in couples. Health centers and counseling can provide community mental health through the creation of weekly educational workshops to increase family sexual awareness.

Incidence of musculoskeletal disorders is one of the effects of inappropriateness between subjects and technology, which reduces the level of human immunity, occurrence of occupational disabilities, loss of working time and increasing costs. The aim of this study was to evaluate risk factors of musculoskeletal disorders for assemblers in an electric industry workerand effect of interventions on reducing the level of these disorders.

This interventional study was carried out among 75 women workers in a wall plug factory having more than one year working experience in 2017. The data collected were analyzed by using SPSS software version 20 and Chi-square, regression, independent t-test, after reviewing medical documentation and completing QEC and Nordic questionnaires before and after ergonomic interventions which was done in the form of training and corrective actions.

According to the results, the highest reported musculoskeletal disorders were in the shoulder, wrist, lower waist, upper lobe with frequency of 68%, 61%, 58% and 51%, respectively, that with respect   to ergonomic interventions, this reduction for each area was 60%, 46%, 49% and 46%, respectively, which was relatively a good reduction in abnormalities.

The interventions in this industry have shown the effectiveness of these methods for reducing musculoskeletal disorders, and it can be concluded that educational interventions and making activities periodically together have been effective in reducing disorders.