مجله دانشکده پزشکی اصفهان
پیاپی 714 (هفته دوم خرداد 1402)

Non-communicable diseases or NCDs including but not limited to cardiovascular diseases or CVDs, cancers, diabetes mellitus or DM, high blood pressure or hypertension, COPD or Chronic obstructive pulmonary disease, etc. are the most important cause of death in the world, and estimates indicate that this trend will continue in the coming years. This is despite the fact that many of the factors that cause the mentioned diseases, (including smoking, obesity, inactivity, alcohol consumption, and stress) can be prevented or controlled to a large extent. Lifestyle medicine is a specialty in medicine, which uses interventions to prevent and even treat those diseases that are related to people's lifestyle. This approach includes 6 principles; healthy eating pattern, ample physical activity, restorative sleep, stress management, avoidance of risky substances, and positive social connections. In recent years, the use of lifestyle medicine, to treat non-communicable diseases or NCDs, has become an accepted approach in the world.

Tissue engineering is a set of methods that can replace or repair damaged tissues with natural or artificial tissue. Tragacanth is a natural polymer that has excellent biological properties such as biodegradability and biocompatibility. Silymarin biochemically has cleansing and antioxidant properties and also has anti-inflammatory effects. The aim of this study is the production of polycaprolactone (PCL) / tragacanth / silymarin nanoscaffold and to investigate the biocompatibility of dental cells on it.

To create a polycaprolactone /tragacanth nanoscaffold and add silymarin to it, acetic acid was used to dissolve 7 percent of the polycaprolactone, 0.7 weight percent of the tragacanth solution, and 0.9 percent of the silymarin solution. The scaffold was then created using an electrospinning machine. Scanning electron microscope (SEM) analysis and FTIR analysis were used to analyze the scaffold's chemical structure and shape, respectively.

The scaffold's correct porosity and the successful loading of silymarin on it were revealed by analyzing the scaffold's morphology and chemical composition. The biocompatibility of the scaffold was investigated 24, 48 and 72 hours after the cultivation of dental cells, and the results showed an increase in cell viability and proper attachment of cells on the scaffold.

The findings of this study demonstrated that silymarin loading on the polycaprolactone/catira scaffold improves dental cell proliferation and survival. This scaffold may therefore be a good choice for tissue engineering.

Regular exercise activity along with the consumption of green tea and green coffee has anti-diabetic, anti-inflammatory, anti-fibrotic, and anti-obesity properties in addition to antioxidant compounds. This study aims to investigate the effect of eight weeks of progressive aerobic activity along with the consumption of green tea and green coffee on fat oxidation and blood pressure in overweight girls.

This research was carried out using a semi-experimental method and a clinical trial in the form of pre-test and post-test. Based on this, 48 people were invited to participate in the briefing session and randomly divided into four exercise groups + green coffee, 12 people (Exe+coffee), exercise group + green tea, 12 people (Exe+tea), exercise group + Green coffee+green tea, 12 people (Exe+coffee+tea) and training group, 12 people (Exe). One day after taking blood in the first stage and measuring physical and physiological indicators in all four groups, the subjects received progressive aerobic training for eight weeks, as well as green tea or green coffee or both depending on the experimental group.

The results of the present study showed that there is no significant difference in the variables of systolic blood pressure, diastolic blood pressure, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol between the four groups, but in the variables of body weight, body mass index, body fat percentage, waist to hip ratio and Triglyceride, the differences between the four groups were significant.

Obese and overweight women can improve their body composition and general health by combining progressive aerobic exercises and consuming green tea and green coffee supplements.