فهرست مطالب

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
سال پنجاه و دوم شماره 4 (پیاپی 106، زمستان 1388)

تاریخ انتشار: 1388/10/11
تعداد عناوین: 10

فارسی
English

انتخاب همه

Evaluation of Subtypes of Peripheral Blood Lymphocytes in Patients

Naser Tayyebi Meibodi, Zari Javidi, Mahmoud Mahmodi Masoud Maleki Yalda Nahidi Monavar Afzalaghaei Bita Safaee Mohammad Ebrahimi Rad Pages 198-202

Introduction
Vitiligo is characterized with white patches on the skin and alteration of melanocytes in dermoepidermal junction. Autoimmune mechanisms with an underlying genetic predisposition are the most likely causes of vitiligo. This study was performed to evaluate immune disturbance in vitiligo and clarify its more details.
Materials And Methods
A total of 29 vitiligo patients and 21 healthy controls were included in this case control study.Complete blood count was measured and peripheral blood samples were evaluated flowcytometrically for surface antigenic markers including CD3, CD4, CD8, CD19, CD16, CD56 and CD25 for determining the percentage and total number of various lymphocyte subgroups. Patients with different clinical subtypes were compared with each other and controls in terms of the flowcytometry results. Obtained information was assessed by SPSS statistical software.
Results
Total numbers of CD3+, CD8+ T cells, B cells and CD25+ cells were significantly increased in generalized type vitiligo patients in comparison with localized type. CD25+ cells were also increased significantly in generalized and stable types of vitiligo compared with healthy controls and finally the total number of lymphocytes was significantly decreased in localized type vitiligo patients in comparison with healthy controls.
Conclusion
Our data indicate cellular immune disturbance in vitiligo. Disorders of immune regulatory system may play a major role in this context. Significant CD25+ or regulatory T cells increment in different clinical subtypes of the disease is in favor of the above hypothesis. Later and larger studies may result in new and effective routs of treatment for vitiligo acting through regulating immune system.
Keywords: Flowcytometry, Lymphocyte, Peripheral blood, Vitiligo

Abstract View Paper Original: Persian
Right Ventricular Function before and after an uncomplicated Coronary Bypass Graft as Assessed by Pulsedwave Doppler Tissue Imaging of the Tricuspid Annulus

Afsoon Fazlinejad, Afsaneh Mohammadi, Behrouz Mottahedi, Jamil Esfahanizadeh Pages 203-208

Introduction
RV function using myocardial velocities before and after a CABG is unknown. CABG on the beating heart without cardiac- pulmonary bypass (off- pump) has gainad increasing popularity. Improved post operative ventricular function has been cited as an advantage over on- pump surgery.
Materials And Methods
A total of 36 pts (26 male and 10 female) with significant coronary artery disease underwent elective CABG, between March 2005 and June 2006. All had pulsed wave TDI and mmode imaging obtained from the apex, visualising the tricuspid free wall annulus. Amplitude of TV annulus displacement and RV systolic and diastolic velocities were compared before and 5 days after surgery. Regional mitral annular velocities were also studied for comparison.
Results
Altogether 21 pts Underwent off- pump CABG. Each subject had a mean 2.6 grafts. All left ventricular regional velocities showed a non significant reduction after surgery. TAM and both systolic (S) and diastolic (E & L) velocities in the RV decreased considerably 5 days after CABG. S 12.6 vs 7.7, E 10.8 vs. 7, A 6.6 vs 9, (p=0.000). The off- pump group had a similar trend with no evidence of preserved RV function compared to the on- pump group.
Conclusion
Systolic and diastolic RV function, as assessed by DTI and TAM decreased significantly after CABG. TDI can provide a simple and noninvasive qualitative method for assessing and monitoring of RV function after surgery. Off- pump CABG cannot prevent this malfunction.
Keywords: CABG, Echocardiography, Function, Right ventricular, Tissue Doppler

Abstract View Paper Original: Persian
The Relationship of Level of Maternal Serum Copper and Zinc with Neonatal Birth Weight

Hassan Boskabadi, Gholamalimamouri, Mehran Nori, Hosein Ayatollahi, Habib Esmaeily Pages 209-214

Introduction
Minerals and trace elements such as zinc and copper have significant influence on development and growth of fetus and newborn. The purpose of this study was to determine the relationship between low birth weight and maternal, neonatal zinc, copper status.
Materials And Methods
This is a case-control study, which was done in Ghaem hospital, Mashhad University over one year from September 2006 to September 2007. The study consisted of 65 infants with birth weight < 2500 gr and 65 infants with ≥ 2500 g and their mothers’ as case and control groups, respectively. Cord and maternal blood samples collected at delivery were analyzed by atomic absorption spectrophotometry for zinc and copper levels.
Results
Mean serum zinc levels in maternal and the cord blood were 6.35+2.09 mmol/l, 12.77+3.83 mmol/l and 7.57+1.75 mmol/l, 13.18+2.69 mmol/l of case and control groups, respectively (p<0.05). The mean copper levels in maternal and cord blood were 21.82+4.45 mmol/l, 5.12+1.54 mmol/l and 21.19+5.34 mmol/l, 3.65+2.04 mmol/l of control and case groups, respective (p<0.05).
Conclusion
This study indicated that mothers with the zinc level of less than 6.4 mmol/l were 3.8 time more at risk of having infant with the birth weight of less than 2500 gr. Lower maternal weight, was associated with increased risk of having low birth weight infants.
Keywords: Copper, Infant Low Birth Weight, Mothers, Neonate, Zinc

Abstract View Paper Original: Persian
Assessment of Bone Density in Patients before and after Kidney Transplantation

Mohammad Javad Mojahedi, Farzaneh Sharifipour, Maryam Hami, Masoud Saghafi, Bita Dadpour, Nayereh Saadati Pages 215-219

Introduction
Accentuation of bone loss is one of the most important skeletal complications after transplantation. Early diagnosis and treatment of osteopenia and osteoporosis reduce risk of fractures and prevent the aggravation of it by using corticosteroid after kidney transplantation.
Materials And Methods
A total of 50 patients that received graft during the research time, 31 of them completed it. They were screened for decreased bone mineral density at baseline, 6 and 12 months after transplantation with dual-energy x-ray absorptiometry (DEXA) of lumbar spine and hip.
Results
A total of 31 patients [17 (55.8%) female and 14 (45.2%) male] with end stage renal disease entered the study. The mean age of patients in both genders were 39.67±14.5 years (range: 20-67years). Replacement therapy in 24 patients (77.4%) was hemodialysis and in 7 patients (22.6%) was peritoneal dialysis. Before transplantation, the mean of T-score in femoral neck and lumbar vertebra were -0.88±1.19 and-0.37±1.12 respectively, osteopenia was found in 41.9% and 29% of each region. On 6 months after transplantation, the mean of T-score in femoral neck and lumbar vertebra -1.42±0.95 and -1.41±1.36 respectively. Incidence of osteopenia in each region was 83.9% and 64.5% in turn. We tried to examine them in the first year after transplantation, the mean of T-score in femoral neck was-1.13±1.11 and in lumbar vertebra was -1.29±1.33. After 6 months, bone mass reduction was significant (p<0.05), but there was not any significant difference between 6 and 12 months following transplantation (p>0.05).
Conclusion
Bone losswas highest in the first 6 months after transplantation. Then, treatment was necessary during this period of time.
Keywords: Bone densitometry, Renal Transplantation, Osteopenia, Osteoporosis

Abstract View Paper Original: Persian
Surgical Treatment and Outcomes of 10 Cases with Cardiac Echinococcosis

Ali Reza Molavipour, Ali Reza Abdollahi, Hassan Dastani, Maryam Mojtabavi Pages 244-248

Introduction
Cardiac echinococcosis is an uncommon and potentially fatal complication of hydatid cyst disease, which has an intricate diagnosis and treatment because of various presentation, diverse signs and symptoms, and abundant and sometimes unpredictable complications. This study reviewed the results of surgical treatment of 10 cases of cardiac echinococcosis.
Materials And Methods
This case of series was done in ten cases of cardiac echinococcosis underwent surgical treatment at Shahid Madani Heart Hospital, Tabriz, in a 12 years period (1992-2004). For collecting data a questionnaire was used and statistical analysis was performed with SPSS software and descriptive statistical methods.
Results
There were 7 female and 3 male patients (F/M Ratio=1.75/1). The mean age of patients was 24.6 years old. All patients operated through median sternotomy with cardiopulmonary bypass. Surgical treatment included puncture of cyst and sterilization with hypertonic saline solution and total cyst extirpation. There was preoperative mortality and cerebral hydatid cyst occurred in another patient one year later. All patients received albendazol pre- and post-operation.
Conclusion
According to the results of this study, surgical treatment of cardiac hydatid cyst seems to be a safe approach. It is recommended that patients should receive mebedazole or albendazole for 6 to 24 months after surgery. Reduction of serum levels of antibodies against echinococcus or a negative result signifies a successful treatment.
Keywords: Cardiac echinococcosis, Outcome, Surgical treatment

Abstract View Paper Original: Persian

علمی مصوب

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد

Medical Journal of Mashhad University of Medical Sciences

دوماهنامه پزشکی

آخرین شماره | آرشیو

ISSN: 1735-4013

صاحب امتیاز:

دانشگاه علوم پزشکی مشهد

مدیر مسئول:

دکتر عبدالله بهرامی

سردبیر:

دکتر غلامحسین کاظم زاده

تلفن نشریه: ۰۵۱-۳۸۵۳۳۶۳۰

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فهرست مطالب

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد سال پنجاه و دوم شماره 4 (پیاپی 106، زمستان 1388)

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد

Medical Journal of Mashhad University of Medical Sciences

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
سال پنجاه و دوم شماره 4 (پیاپی 106، زمستان 1388)