جستجوی مقالات مرتبط با کلیدواژه « کارسینوم پستان » در نشریات گروه « پزشکی »

breast cancer is currently the most common cancer among women, and is a multi-stage disease. The EBV virus is known to be a major contributor to human cancers. The development of breast cancer in humans is often regulated by steroid hormones, such as estrogen and progesterone. The aim of this study was to simultaneously investigate the expression of the EBV BXLF2 and the human PR / ER gene in breast cancer patients referred to the l Tabriz International Hospital.

this descriptive cross-sectional study was performed on 50 women with mean age of 57.3 years Genomic DNA extraction from specimens was performed using the saturated salt method. The cDNA was then synthesized from the extracted RNAs. Real-time PCR was used for the expression of the BXLF2 gene, the detection of the EBV genome, and the determination of the PR / ER gene.

as breast cancer progressed, the expression of ER increased significantly and with the increase in the stage of the disease, the level of expression of PR decreased significantly (p-value = 0.0043). A weak correlation was found between age and viral title. There was a significant relationship between the presence of progesterone receptor gene expression and virus load in the affected person. (P-value <0.001).

In progesterone receptors, the expression of the receptor gene in the first three steps was approximately one-and-a-half times, which then decreased at different stages, the expression of the estrogen receptor expression increased. There was a weak correlation between age and EBV titers (P-value <0.001)

Upper limb lymphedema is a rather common and debilitating sequel of breast cancer treatment. The incidence of this sequel has been reported at different rates by different sources ranging from 6% to 31%. The aim of this study was to evaluate the incidence and risk factors including age، body mass index (BMI)، region and size of the tumor، presence of metastasis، number of metastatic lymph nodes، excised axillary lymph nodes، type of surgery and radiotherapy and chemotherapy following the invasive breast carcinoma treatment.

Through a retrospective study، recorded data from 170 breast cancer patients referred to Seyed Al-Shohada Hospital، Isfahan، Iran، during 2001 to 2006 was evaluated for the lymphedema incidence and risk factors.

59 patients (34. 7%) with mean age of 47. 9 ± 10. 9 had lymphedema. In univariate analysis، obesity، estimated by BMI، was significantly associated with the development of lymphedema (P = 0. 002). The number of metastatic lymph nodes in patients with and without lymphedema had a significant statistical difference (P < 0. 0001). Age، excised nodes، type of surgery، region and size of the tumor، presence of metastasis، radiotherapy and chemotherapy had no associations with the incidence of lymphedema.

According to our findings، the number of metastatic lymph nodes as well as BMI was associated with the development of lymphedema with higher incidence in patients with higher BMI and more affected lymph nodes.