The Effects of Feeding with Ferrous and Unicellular Yeast Enriched with Organic Chromium on the Blood Factors in Streptozotocin-induced Diabetic Male Rats

Chrome is regarded as an essential nutrient required for glucose and lipid metabolism, specifically in diabetic patients. Converting mineral form of chromium to organic as well as increasing its absorption seem to have more fruitful therapeutic effects due to the synergistic effect of these two anti-diabetes compounds(yeast and chromium). Therefore, the present study aimed to evaluate the effects of iron and chromium-enriched yeast with a probiotic nature on blood factors in diabetic male rats. In this laboratory experiment, 49 Wistar male rats weighed 30±200 were randomly divided into 7 groups and then were induced with diabetes via an intra-peritoneal injection of streptozotocin. Organic chrome was prepared via chromium enrichment in yeast cells, food treatment by dissolving the yeast and iron of different concentrations in physiological serum, which was sprayed in the rats’ food. Furthermore, blood factors such as glucose were measured applying enzymatic method via an auto analyzer. The study data were analyzed utilizing one-way ANOVA and Tukey tests. The results of the current study revealed a significant reduction in blood glucose, cholesterol, triglycerides, and LDL, though a significant increase was observed in HDL of the male rats treated with iron as well as with iron and organic-chromium combination. Moreover, it was demonstrated that iron diet could significantly increase the blood glucose, cholesterol, triglycerides, LDL, whereas it simultaneously decreased HDL in diabetic male rats(p <0.05). The study findings revealed that yeast enriched with probiotic-derived chromium can lead to appropriate changes in blood glucose, and serum lipids in diabetic rats. Moreover, treatment with iron increases glucose levels and causes undesirable changes in blood serum lipids of diabetic rats.