جستجوی مقالات مرتبط با کلیدواژه « gorgan » در نشریات گروه « پزشکی »

The current research delves into ethnopharmacology, specifically focusing on the influence of extraction solvent on parameters such as total phenol, flavonoid, coumarin, tannin, antioxidant, and antibacterial activity. This investigation spans different parts of Melilotus officinalis L. within two northern provinces of Iran. It is a holistic approach, exploring both traditional applications and the scientific impact of extraction methods on the plant’s bioactive properties.

In various observational studies across different fields, ethnopharmacological data were acquired by collecting various parts of the M. officinalis plant (flowers, stem, and root) at different blooming stages from Charbagh Mountain (2340 msl) and Gorgan region (200 msl) between June and July 2016. “Ethanol and water extracts” of these plant parts were obtained through the maceration method. The quantification of “total phenol” (TP), “flavonoid” (TF), coumarin (CO), and tannin (TA) content in the extracts was conducted using spectrophotometry. The in vitro “antioxidant capacity” of the extracts was assessed through the DPPH free radical scavenging assay, the total antioxidant capacity (TAC) assay, and the reducing power assay. Additionally, the antibacterial activity of the extracts was examined against nine gram-positive and gram-negative bacteria using disc diffusion and minimum inhibitory concentration (MIC) assays.

Based on the results, the ethanol extract obtained from the flowers of M. officinalis collected at a high altitude (2340 meters) in Semnan province demonstrated the highest concentrations of total phenols (38.08 ± 0.13 mgGA/g), flavonoids (62.04 ± 0.01 mgQU/g), coumarins (19.32 ± 0.08 mL/g), and tannins (33.89 mg/g). Notably, coumarin and tannins were absent in the water extract. The ethanol extract from the flowers in Semnan province exhibited superior antioxidant activity, particularly in the DPPH method (IC50=10.61 ± 0.81 µg/mL), surpassing the efficacy of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Moreover, the ethanol extract from high-altitude flowers displayed potent antimicrobial activity against gram-positive bacteria, specifically Staphylococcus aureus, S. epidermidis, and Bacillus cereus, with inhibition zone (IZ) values of 19.1 ± 0.01 mm, 15.8 ± 0.2 mm, and 14.4 ± 1.12 mm, respectively. The MIC values against these bacteria were 24.5 μg/mL, respectively. In summary, the ethanol extract exhibited greater effectiveness against gram-positive bacteria compared to gram-negative bacteria.

Our results indicate a robust association among the extraction solvent, plant part, phytochemical composition, antibacterial efficacy, and antioxidant potential of M. officinalis L. Specifically, the ethanol extract derived from the flowers displayed the most significant antioxidant and antibacterial characteristics. This implies that the ethanol extract from the flowers of M. officinalis L. holds promise as a valuable reservoir of natural antioxidants, aligning with its traditional utilization in addressing various infections.

The hepatitis B virus (HBV) is a major public health problem worldwide. Vertical and horizontal transmission of HBV could affect neonates and partners. This transmission can vary in populations. Also, high-risk behaviors and clinical records affect the transmission of this virus. Due to the lack of information on vaginal discharge related to HBV in the north of Iran, we aimed to assess the presence of HBV in pregnant women's vaginal secretion referred to Sayyad Shirazi Hospital in Gorgan City, north of Iran.

This cross-sectional study was performed on 315 cervicovaginal lavages from pregnant women. Viral DNA was extracted, and the gene fragments of the virus were checked by polymerase chain reaction (PCR). Clinical, demographic, and behavioral data were entered into SPSS version 16. The chi-square tests were used to determine any association between categorical data.

Hepatitis B virus DNA was detected in 2.2% (7/315) of samples. The age range of patients was from 14 to 43 years. Anal sex (P = 0.043) and not using a condom (P = 0.047) were significantly associated with HBV-positive cases. Abortion, unusual discharge, and some other clinical and demographic information showed no related statistical correlation.

The results showed a similar rate of infection in the general Iranian population. In pregnant women, the risk of HBV transmission and chronic HBV can be critical in newborns; therefore, it is strongly recommended to conduct screening and provide management for women during pregnancy.

The present investigation has been done to study the behavioral effects of donepezil in autistic children, given that not much research has been carried out concerning using this drug for treating autism.

A cross-sectional and analytic-descriptive study was done on twentypatients with autism, aged 4-17, who visited the neurology clinic of Gorgan’s Taleghani Pediatric Hospital and Yasha Pediatric Autism Clinic, Iran from 2019 to 2020. Demographic information, including sex, age, father’s education, mother’s education ,patient’s education, family status, other problems, and ethnicity, were documented using a checklist, having been filled in during interviews with the parents. Before the trial, ABC cognitive and behavioral tests were taken to determine the children’s current status. After the tests, these children received a daily dose of donepezil (10mg) before sleep for three months. At the end of the three months, the cognitive and behavioral tests were taken from the children once again. In order to analyze the effects of different factors on the studied variables, including irritability, lethargy, stereotypic behavior, hyperactivity, and inappropriate speech before and after the administration of donepezil in patients, a generalized linear model and to test the effects of donepezil on the studied variables, paired t-test was used.

In this study, twenty patients were registered for the investigation, 12 (60%) male and eight (40%) female. Age groups 5-6 had the highest frequency, and age group 17 had the lowest. Regardingthe parents’ education, the highest frequency was for bachelor’s degrees, and the lowest was for less-than-high school education and master’s degree. The highest frequency for the patients’ education was kindergarten (60%), and then groups without education (20%) and elementary school-level education (15%). Most of the studied patients (80%) did not have other problems besides autism, and only 20% had other problems besides autism. The family status of 15% of the families was ‘separated,’ and ethnically, most patients (80%) were Fars, while the rest (20%) were Turkmen. None of the analyzed factors (age, sex, father’s education, mother’s education, patient’s education, other problems, family status, and ethnicity) had a significant effect on the studied variables after the administration of donepezil. Among the studied variables prior to the administration of donepezil and among the analyzed factors, the father’s education, the patient’s education, other problems, and family status had only a significant effect on stereotypic behavior. The present research findings of the present research indicated that all the studied variables, including irritability, lethargy, stereotypic behavior, hyperactivity, and inappropriate speech, were significantly decreased toward the desired goal. The decreased amounts in irritability, lethargy, stereotypic behavior, hyperactivity, and inappropriate speech after the administration of donepezil were, respectively, 38%, 44%, 54%, 41%, and 54% and on average, these behaviors were reduced by 46%.

The present investigation has shown that all the studied variables, including irritability, lethargy, stereotypic behavior, hyperactivity, and inappropriate speech, were significantly decreased towards the desired goal by 46%. This significant decrease is indicative of the effectiveness of the treatment of autism patients with donepezil, and therefore, this drug can be placed as a prominent and essential part of the medical therapy of autism.

Time management skill learning and identification are very effective in the study process, and can reduce the adolescentschr('39') waste of time and help them increase the academic achievement. The present study aimed to determine the effect of time management skill on the academic achievement of female students.

This interventional study was a randomized controlled field trial. The statistical population consisted of all 2785 female second-grade high school students in 2017-2018 covered by health centers of Gorgan, Iran. Forty eligible students were selected and allocated into intervention and control groups. In the intervention group, a group counseling session of time management training was held for 6 hours in two days. A month after intervention, all students completed the questionnaire, and the studentschr('39') grade point average (GPA) of the first and second semesters were extracted in 2017-2018. To compare the academic achievement we used the Mann-Witny U test, paired t-test, and Wilcoxon test in SPSS-16.

The mean of the GPA of students in control group before and after intervention were 17.95±1.47 and 17.86±1.67, respectively (P=0.43). The GPA in the intervention group was 17.61±0.84 before intervention and showed an increase to 17.75±1.08 after the time management skill training; but the increase was not statistically significant (P=0.43). The results indicated a statistical significant difference in mean scores of 2 subscales; short-term planning and time attitude in the intervention group in comparison with the control group.

Despite the fact that time management skill training did not lead to the academic achievement in students, it could improve the short-term planning. Since the follow-up of the present study was short-term, it needs time to improve planning and affecting the academic achievement. It is suggested to examine this assumption in longitudinal and long-term studies.

Poisoning is a common cause of hospitalization in intensive care units (ICU). The present study aimed to investigate   the frequency of poisoning leading to hospitalization in the intensive care units of an educational hospital, Golestan University of Medical Sciences, in Gorgan in 2008-2018.

This cross-sectional study conducted on patients with acute poisoning admitted to the ICUs of 5 Azar Hospital in Gorgan from 20 March 2008, to 20 March 2018. We collected data from all patientschr('39') medical record using a checklist.  Data was presented in proportions, mean and standard deviation.

All of 631 patients with poisoning were admitted to the ICUs were male (61.3%) and 40.3% were in the age range of 20-29 years. The mean length of hospital stay in the ICU was 4.21±3.45 days. The most common type and cause of poisoning were suicide attempt (65.3%) and drugs (65.6%), respectively. The common drugs were used including the benzodiazepines (38.9%) and narcotic drugs (18.6%). The rate of death of poisoning was 11.1%, of which 44.3% was due to aluminum phosphide.

Benzodiazepines and aluminum phosphide were the most common causes of poisoning and death due to poisoning in the ICU. Due to the high mortality rate, it seems necessary to provide more education and information via the media, especially in the field of aluminum phosphide hazards.

Currently, due to an increase in the number of individuals with immune deficiency, long-term chemotherapy, and underlying diseases, an appropriate situation has been provided for the development of opportunistic infections, including fungal infections. This study was conducted with the aim of evaluating clinical symptoms, laboratory findings, and the treatment outcome of mucormycosis in diabetic individuals.

In this cross-sectional retrospective study, all recorded cases of mucormycosis in the health centers of Gorgan city, northeast of Iran, in diabetic individuals were extracted during 15 years from 2002 to 2016. All information was extracted from patient-related records and then was analyzed. In the period from 2002 to 2016, 12 diabetic individuals with mucormycosis were referred to health centers.

There were statistically significant differences in the categories of sex, residence, education, taking drug, addiction, diabetes status, methods of diagnosis, involved area with mucormycosis, treatment type of mucormycosis, and treatment outcome of mucormycosis. Furthermore, no statistically significant difference was observed in the categories of age, underlying diseases (other than diabetes), hospitalization, and diagnostic time.

Due to the rareness or lack of an appropriate diagnostic method, and in addition, due to lack of an appropriate treatment, attention should be paid to invasive mucormycosis in individuals with immunodeficiency.