جستجوی مقالات مرتبط با کلیدواژه « آکنه » در نشریات گروه « پزشکی »

Acne is a very common psychosomatic disorder that causes physical, psychological and social effects in individuals. This study aims to answer this question: Can interpersonal emotion mediate the relationship between perceived stress and the severity of acne. Is the severity of acne directly related to the total scores of interpersonal excitement and does it support the relationship between acne and stress?

This is a descriptive predictive study method. 93 15-to-50-year-old patients with acne skin disorder were included in the study using convenience sampling method. the GAGS rating scale was used for the severity of the disease. Cohen Perceived Stress Questionnaire and Interpersonal Emotion Regulation Questionnaire were also used. Finally, the data were analyzed using regression and path analysis.

Perceived stress in patients with acne had an inverse effect on emotion regulation and the amount of its effect was -0.27 and significant (P <0.01). The amount of relationship between perceived stress and acne severity is 0.30, positive and significant (P<0.01). In addition to these findings, emotion regulation had an inverse effect on acne severity, the amount of relationship was -0.18 and was not significant (P<0.05).

Strategies for regulating maladaptive emotions in patients with acne vulgaris may be associated with higher psychological symptoms and lower beliefs about the effectiveness of treatment.due to the frequency of this disorder and its impact on social and emotional functioning of individuals, the need for further investigation to prevent and treat the disorder is also essential.

Acne is a chronic inflammation of pilosebaceous units and in severe form reflects a different response to treatment in an oral regime of antibiotics. The purpose of this study is to compare the effect of the combination of erythromycin and low dose oral isotretinoin with erythromycin and low dose flutamide in women suffering from severe acne.

In a randomized controlled clinical trial, 80 women suffering from severe acne participated in the study and they were studied for 2 months. The first group received 800 mg oral erythromycin, together with 20 mg oral isotretinoin every two days and the second group received 800 mg erythromycin, together with 62.5 mg flutamide daily. The treatment efficiency was evaluated by the count of acne lesions and computing the acne severity index. The data of the study were analyzed using the version 16 of spss software.

In the present study, 40 patients participated in the research in each group. Finally, 61 people completed the study. The mean acne severity index in the flutamide group was 195.9±15 at the beginning of treatment and this index reduced to 52.8±5.8 at the end of treatment. The mean acne severity index in the isotretinoin group was 247.8±19.7 at the beginning of treatment and this index reduced to 76.3±12.5 at the end of treatment. The difference in reduction between the two groups was not statistically significant (p=0.15).

The treatment effectiveness of the above-mentioned methods in female severe acne was acceptable and this combination therapy can be presented as a better alternative compared to treatments with high dose individual treatment including oral isotretinoin and oral flutamide.

Acne is the most common dermatological condition worldwide that affects almost everyone once in a lifetime. The consequences of the disease go beyond the few symptoms that appear on a persons face. The significant of this disease should not be overlooked because it can have many adverse psychological and social effects on the patient. This study aims to investigate the knowledge and attitude of adolescents in the south of Iran about acne in 2019.

The present study is a descriptive-analytic and cross-sectional study that carried out among 351 high school students in southern Iran in 2019. The stratified sampling technique has been used in the study. Data collection tools included a researchermade questionnaire for knowledge and attitude toward acne that was completed through self-reporting. Data were analyzed by SPSS software version 23. The significance level was considered less than 0.05.

The mean score of knowledge and attitude about acne were 11.3 ± 3.6 (range=0-27) and 22.8 ± 3.6 (range= 8-32), respectively. Knowledge of acne was low in 9.1% of students, moderate in 87.2%, and high in 3.7%. The attitude toward acne was desirable in 4.8% of students, moderate in 82.8% and poor in 12.4%. The mean scores of attitude were similar in both sexes; howevere, the mean scores of knowledge in females were significantly higher than males (P=0.015).

All in all, the results of this study showed that students’ knowledge and attitude about acne vulgaris are mostly moderate. Based on the results, it is recommended to provide the necessary planning to increase the knowledge and attitude of high school students about acne vulgaris in southern Iran.

Atrophic scars constitute a common complication of acne and various methods have been proposed for their treatment. This study aims at comparing the efficacy of fractional CO2 laser with microneedling in the management of atrophic acne scars.

Patients with atrophic acne scars presenting to dermatology clinic of Hamadan’s Sina hospital between March 2016 and March 2018 were included in the study. Every 3 weeks, each patient received fractional CO2 laser on one side of the face and microneedling on the other side, for a total of 4 sessions. Patient’s satisfaction and the severity of scars (based on Goodman and Baron’s scar scale) were assessed 1, 2 and 6 months thereafter.

Overall, 24 participants were included. Prior to intervention, no significant difference was observed between groups in terms of mean scar score (P =0.726). At 1, 2 and 6month follow-up visits, the scar score of the side treated with laser was significantly lower than the microneedling side (P for 1, 2 and 6month follow-up visits: 0.033, 0.008 and 0.014). No significant difference was observed between groups in terms of patient’s satisfaction (P for 1, 2 and 6 month follow- up visits: 0.589, 0.469 and 0.840). The most prevalent side effect was erythema in 3 patients treated with laser. Due to low prevalence, statistical analysis of side effects between groups was impossible.

Compared to microneedling, fractional CO2 laser was more effective in reducing the scar score of patients. The prevalence of side effects in both treatments were low.

Several adverse effects (AEs) such as ocular AEs have been reported following systemic consumption of isotretinoin. Here, we report a case of bilateral chalazion, conjunctivitis, and hordeolum associated with systemic isotretinoin.

A 20-year-old girl was treated with oral isotretinoin because of severe inflammatory acne, and developed bilateral chalazion, conjunctivitis, and hordeolum about 4.5 months after initiation of treatment. Two weeks after cessation of oral isotretinoin, patient’s eye condition improved. However, after re-initiation of oral isotretinoin treatment with a reduced dose, her conjunctivitis relapsed; therefore, the treatment was once again terminated.

 Since the patient’s condition was bilateral, recovered after cessation of therapy; and once again, relapsed after re-initiation. It was most likely a complication of the medication and not a coincidence.

Acne is a chronic inflammatory disease of the pilosebaceous glands caused by opportunistic microorganisms. The Rhamnus cathartica is known to have biological and antioxidant properties. This research aimed at investigating the in vitro effect of gel containing 5%
R. cathartica extract on acne vulgaris.

The gel formulation contained 25g of dried R. cathartica bark extract, 0.5 liters distilled water, glycerin 50g, carbopol 940 5g, methyl paraben 0.75g, and propyl paraben 0.5g. After 24 hours, the formulation was put outside the refrigerator. Then, triethanolamine was added to the formulation under stirring with 500 rpm to solidify the gel. The effect of the product was measured against Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus and MIC and MBC values were also determined.

Total phenolic content of R. cathartica was 351.6±4.5 mgGA/g/DW, total flavonoid content was 23.15±1.355 mgCE/g/DW, and total anthraquinone content was 1.85 ± 0.05 mgAE/g/DW. The pH of the product was 5.5-6. The MIC values of R. cathartica 5% gel were 195.3 µg/ml, 24.41 µg/ml, and 97.65 µg/ml against C. acnes, S. epidermidis and S. aureus, respectively. The MBC testing showed 25000 µg/ml, 25000 µg/ml, and 12500 µg/ml against C. acne, S. epidermidis and S.aureus.

R. cathartica is believed to contain active ingredients and can act as an antibiotic against acne causing microorganisms.

Acne is a pathological disorder and a chronic inflammation in the sebaceous follicles, and one of the most popular dermatology damages that has affected millions of people worldwide. The aim of this study was to identify Candida species in patients with acne as well as determine the drug susceptibility of these species.
 
Materials & In this cross-sectional study, 70 clinical specimens were taken from the skin of patients suspected of acne by the sterile swab. Subsequently, the specimens were cultured on Sabouraud Dextrose Agar containing chloramphenicol. The plates were incubated for 48 h at 37˚C. The suspected colonies were investigated through microscopic examination and subsequent passages were evaluated according to standard operating procedures and specification of the type of colony color on CHROMagar for the isolation of the yeast. The sequencing method was utilized (ITS2, ITS4) to approve C.species. In addition, the susceptibility testing was performed to assess drug-resistant isolates C. species based on the clinical and laboratory standards institute method.
In total, 11 C. species were identified and isolated that include 8 C.parapsilosis (72.73%), 1 C.krusei (12.5%), 1 C.lusitaniae (12.5%), 1 C.kefir (12.5%), and a Trichosporon asahi. According to the investigation of C. parapsilosis isolates susceptibility to various concentrations of the anti-fungal agents to isolates Cp1and Cp8,  the isolated Cp5 with MIC 50 was equal to 32,0.5,0.25 and with MIC 90 of <64, <1, <0.5 μg/ml were resistant to fluconazole, itraconazole, and ketoconazole, respectively. Apart from the isolation of Cp1 and Cp8, which had relative resistance, almost all other species of C. parapsilosis isolates were susceptible to these drugs.
 
Discussion & Several studies showed that bacterial agents are involved in causing acne in most cases. According to the results of this study, it can be suggested that the yeast C. species can be introduced as an agent in the etiology of this disease. C. species isolates can also be resistant to antifungal drugs and this could be one of the causes of the treatment failures.

Acne scar is one of the most common skin diseases, and although there are many treatments available, these treatments have complications and problems. Therefore, in this study, we aimed to investigate the effectiveness of acne scar pealing with salicylic acid 30% in polyethylene glycol vehicle. In this randomized clinical trial study, 32 patients with scar following acne that did not respond to medication therapy were included. Patients were divided into two groups of placebo (not treated with peeling and received only medication) and intervention (under peeling with 30% salicylic acid at polyethylene glycol vehicle for 4 sessions over a period of 6 weeks). Weighing the severity of their lesions was done before the intervention, using weighted scale, and after treatment using the quartile grading scale. Findings: There was no significant difference in the depth of the weighted scale before the intervention between the two groups (P = 0.37). After intervention, there was a significant difference between the two groups based on quartile grading scale, so that the recovery rate in the intervention group was better than placebo (P = 0.01). In the intervention group, 25% of the patients had at least one drug complication that had a significant difference with placebo group (P = 0.03). Salicylic acid is not only effective in the treatment of acne, but has also been used to improve the acne scar.

Acne vulgaris is a common disorder of adolescence which may lead to significant cosmetic and psychological problems. About 70% of adolescents suffer from acne. One of the most common abnormalities that patients seek for skin care. Acne is a chronic and inflammatory disease that affects the sebaceous glands of the follicles and has a significant outbreak, especially among adolescents and young people. The objective of this randomized, double-blind clinical trial is evaluation of the effect of Finasteride microemulsion gel in the treatment of men with mild to moderate acne. In this clinical trial, 48 men with mild to moderate acne assigned into the study randomly and the subjects divided into two groups A and B randomly. Patients evaluated by a physician in terms of clinical manifestations of acne (number of lesions, acne severity, patient satisfaction). The two groups will be followed up for 3 months. Finasteride microemulsion gel twice in a day and 1% Clindamycin phosphate topical gel twice in a day will be administered for three months for group (A) and 1% Clindamycin phosphate topical gel twice in a day will be administered for three months for group (B). If any complications are detected, the patient will be excluded from the study. Then two weeks, one month, and three months after the intervention will be followed up respectively. The mean age of the patients in the case group was 22.24 ± 0.7 years with a range of 15-28 years old and in the control group 21.7 ± 0.63 years with a range of age from 30 to 16 years. The mean of total papules at the onset of treatment was 3.5 ± 3.5 in the case group and 4.1 ± 4 in the control group and there was no significant difference between the two groups. At the end of the third month, the treatment group had a mean of 0.9 ± 0.3 in the case group and 1.1 ± 0.6 in the control group and the mean difference between the two groups was statistically significant. According to the results of this study, Finasteride microemulsion gel had a good effect on the therapeutic results and it is recommended to doctors and physicians.

The use of medicinal herbs for the treatment of skin disease, such as acne, has a long history. The extract of Pistaca atlantica is used to treat various diseases. This study was designed to evaluate the short-term efficacy and safety of Pistaca atlantica extract for the treatment of mild to moderate acne.
This clinical trial was performed on 60 patients with mild to moderate acne, who where randomly divided into two groups. After obtaining informed consent, volunteers in the case group received a topical extract of 15% Pistaca Atlantica once daily for 6 weeks. In the control group, placebo was given in the same way. Patients were evaluated for the number of lesions at the beginning, and 3 and 6 weeks after treatment.
At the end of study, the mean reduction in lesions was 59.93% in the Pistaca atlantica group and -11.46% in the control group. Also Skin softness and lucidity were observed in the Pistaca atlantica group.
This clinical study showed that topical treatment with Pistaca atlantica extract can be recommended to improve mild to moderate acne. However, a longer study with larger sample size is needed to achieve a comprehensive evaluation of the efficacy and safety of this plant.

Acne, the most common skin disease in polycystic ovarian syndrome, has a prevalence of 83 percent. It is often associated with psychological distress, depression, and anxiety disorders that may impair cognitive functions such as memory, attention, psychomotor speed, and executive functions.The aim of this study was to investigate levels of acne in this group of women and its association with cognitive function, compared to that in healthy women.
The aim of this study was to investigate levels of acne in this group of women and its association with cognitive function, compared to that in healthy women.
In this Case-control study, 45 patients with polycystic ovary syndrome, diagnosed based on Rotterdam criteria, and 45 healthy women as control group were selected. Acne levels of the participants were evaluated by Global Acne Grading System (GAGS). Also, cognitive functions were assessed using the Montreal Cognitive assessment (MoCA).
The average (± SD) acne score in patients was 11.73± 6.87 and in control group was 8.42±6.27, p-value=0.01, which was statistically significant. Also, the difference between the average cognitive function scores in patients (22.68±3.57) and control group (24.71 ± 2.57) was statistically significant (p-value=0.003). However, no significant relationship was found between cognitive function and levels of acne(r=-0.14, P=0.17).
The prevalence of acne in patients with PCOS is more than that in normal counterparts. Also, the prevalence of mild cognitive impairment was higher among patients. No relationship was observed between acne level and cognitive impairment in our PCOS study group. Further prospective studies are needed to confirm these findings.

Acne is one of the most common skin diseases that affect nearly 85% of people in different periods of life. It can affect various individual and social aspects of personality, including self-concept, self-esteem and perfectionism. The purpose of this study was to investigate the relationship between self-concept, self-esteem and perfectionism with acne severity in adolescents.
This descriptive cross-sectional study was carried out on junior high school and high school students in Jolfa city, western part of Iran (2013). In this study, 200 adolescents with acne were selected through purposeful method of sampling. The instrument used in the study included Saraswot self-concept questionnaire (1984), Rosenberg Self-Esteem Questionnaire (1965), and Hewet and Felt Multidimensional Perfectionism (1991). Data were analyzed using descriptive statistics, Pearson correlation and regression analysis.
The findings of the study showed that self-concept and self-esteem had a significant negative relationship with acne severity (r= -0.36, r= -0.83, P≤0.01 respectively). On the other hand, perfectionism has a significant positive relationship with the severity of acne (r= 0.58, P≤0.01). Also, the results showed that in predicting the severity of acne, self-esteem plays a very important role (β= -0.75, P≤0.01).
According to the findings of the study, adolescents are vulnerable to the psychosocial effects of acne. On this basis, considering mental health care along with medical treatment is necessary in acne treatment.

Acne is one of the most common diseases in dermatology. It has been claimed that acne and weight gain are clinical markers of hyperandrogenism, and it seems that obesity is associated with increased responsiveness to androgenic hormones and acne severity. This investigation may aid in finding the possible relationship between severity of acne and Body Mass Index (BMI) in order to improve the management of acne patients.
This was a case-control study. After signing a consent form, 220 individuals that had referred to the outpatient clinic of dermatology of Hamadan Farshchian Hospital were recruited. All of the participants in the study population were females. There were a total of 110 patients with acne serving as the case group and 110 females, without acne as the control group. Two groups were age-matched and compared with respect to BMI.
There was a significant relationship between weight and acne )P = 0.001), yet no correlation was found between acne severity and BMI )P = 0.348).
This study showed that acne and weight are related. Since overweight and metabolic syndrome is associated with higher risk of cardiovascular disease and diabetes, identification and treatment of obesity in these patients is essential. Therefore, it could be suggested that control of obesity and metabolic syndrome may also improve management of acne patients.

Acne vulgaris is a common skin disease and oral isotretinoin is the only treatment that is dramatically effective on its severe type The aim of this study was to evaluate the effects of oral Isotretinoin on the level of sex hormones and menstrual cycle in female patients with severe acne.
In this before and after treatment study, 50 patients with severe acne vulgaris whom were referred to the dermatology clinic of Amir-Almomenin Hospital in Tehran in 2015 and 2016, were recruited. The inclusion criteria were female gender, age between 18 to 50 years, and having severe acne. Exclusion criteria were: pregnancy, lactating, and suffering from other diseases which could confound the study results. The prescribed dose of the oral isotretinoin was 0.5 mg/kg/day for three months. Before initiation of treatment and after three months of treatment serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, and total and free testosterone were measured and compared.
The mean ± standard deviation (SD) age of the patients was 26.0 ± 7.1 years, and 10% of them had polycystic ovary syndrome (PCOs). After taking isotretinoin, 33 (66%) of patients had no change in their menstrual periods, while 3 (6%) had oligomenorrhea, 4 (8%) had amenorrhea, and 10 (20%) had dysmenorrhea. After treatment, mean serum LH levels significantly increased (P=0.001), but FSH, estradiol, and total and free testosterone serum levels did not change statistically (P>0.05).
This study showed that oral isotretinoin can increase the level of serum LH and cause changes in menstrual cycles.

Acne vulgaris is a common skin disorder. This study was conducted to evaluate the impact of Ramadan fasting on acne healing in patients admitted to the dermatology clinic, Razi Hospital, Tehran.
In this prospective cohort study, 10 fasting persons (9 women and 1 man) and 10 non-fasting persons (9 women and 1 man) with acne were studied. Their baseline acne severities were recorded and acne improvement was evaluated in both groups after Ramadan month.
Acne improvement was 71% in fasting persons and 49% in non-fasting persons. Improvement in fasting persons i.e. was 1.4 times of non-fasting ones (P=0.158). However, no significant statistical difference was detected. Also, it was determined that improvement was different according to acne grading. Improvement in acne lesions in patients with grade 2 severity was 100%, in those with grade 3 acne was 78%, and in patients with grade 4 acne was 35 % (P=0.025). But in non-fasting patients there was not a statistical difference between acne severity and improvement rate. Furthermore in patients younger than 24, improvement rate of acne was 1.6 fold more than non-fasting persons and in patients older than 24, this ratio was 1.3 (P=0.011).
This study did not show any statistically significant difference in acne improvement between who were fasting and who were not during Ramadan. Studies with larger sample size are recommended.

Effect of stress on acne is still challenging, but some studies deny this hypothesis. This study aimed to determine the relationship between stress and Acne among high school girl students in Bojnurd.
Material & This analytical cross-sectional study. Two hundred (200) students were selected by simple random. A tool used was the standardized stress questionnaire of Harry. Having or not acne was clinically diagnosed by a dermatologist Data was analyzed using independent sample t test and chi square test, and SPSS software package (version 21).
Of participants, 167 girl students (83.5%) suffered from stress and tension. Almost 33 students (16.5%) were normal. The mean score of stress was 155.71 in the group of Acne and 155.75 in the control group. The mean difference was not significant between two groups (p=0.991). The ratio of tension in the Acne group was 82% and in the control group 85%. There was no significant ratio between groups (p=0.568).
Our findings showed that the prevalence of Acne was high in theses girl students, and the stress level was high in high school girl students in both groups, but there was no significant relationship between stress and Acne in them. It is suggested to perform further studies.

Hirsutism is defined as the presence of terminal hairs in androgen dependent areas like upper lip, cheeks, chin, breasts, lower area of abdomen and thigh in women. The aim of this study was to determine the etiologic factors and clinical features of hirsutism in premenopausal women.
In this cross-sectional study, 180 premenopausal women with hirsutism who were admitted at a referral dermatologic clinic in a 1-year period were investigated. After taking full medical history and performing physical examinations, a transabdominal ultrasonography of the ovaries, and laboratory evaluation including early morning total and free serum testosterone, prolactin, dehydroepiandrosterone sulfate, FSH, LH and 17-hydroxyprogestron in all patients were performed.
The most common causes of hirsutism were idiopathic (51.1%), polycystic ovarian syndrome (37.7%), hyperprolactinemia (4.4%), adrenal hyperplasia (3.8%), and drug-induced (2.8%). Hirsutism was mild in 93 (51.6%) patients, moderate in 78 (43.3%) patients and severe in 9 (5%) patients. Family history of hirsutism was present in 100 patients. Clinical conditions associated with hirsutism were: acne (58.3%), obesity (55.5%), menstrual irregularity (38.8%), androgenic alopecia (17.7%) and acanthosis negricans (8.4%).
Idiopathic hirsutism and polycystic ovary syndrome were the most common causes of the hirsutism in premenopausal women. Obesity also had a significant role in hirsutism occurrence.

West Nile virus (WNV) is a member of the genus Flavivirus that can cause viral infections in human. This study aimed at detecting IgG antibodies against WNV in patients of two cities of Neka and Shiraz. The participants were 46 possible WNV case from Neka (13 women and 10 men) and Shiraz (10 women and 13 men). IgG assay was carried out using the Elisa method. Immune Status Ratio (ISR) in Neka was negative for WNV IgG, but 12 from Shiraz, including 2 women and 10 men, were positive for WNV IgG that was changed from 3.12 to 38.6. Considering ISR, there was significant variation between Neka and Shiraz (p<0.05). In addition, results showed that there was significant variation in WNV infection rate between men (39.19%) and women (13.04%) from Neka and Shiraz cities (p<0.05). Because Shiraz has hot and semi-dry climate, whereas Neka temperate climate, the results were affected by climate variation. Given the outdoor job of men compared to women, they are exposed to the bite of mosquito vectors that transmit WNV.

Acne vulgaris is considered as one of the most common disorders for which، patients seek dermatologic care. In the current study، we evaluated the efficacy of the 5% nicotinamide gel versus 2% clindamycin gel in the treatment of the mild to moderate acne vulgaris.

This randomized، controlled clinical trial was performed in 2009-2010. Sixty female patients with mild or moderate acne vulgaris were recruited to be treated either with 5% nicotinamide or 2% clindamycin gel for 8 weeks. Acne severity index (ASI) was used to evaluate the response to treatment and SPSS software was used to analyze the data.

The mean of ASI at the baseline was 16. 85 ± 8. 50 and 18. 20 ± 12. 27 in nicotinamide and clindamycin groups، respectively (P > 0. 0500). The mean of ASI was significantly decreased compared with baseline during the time in both groups (P < 0. 0001). However، there was not any significant difference regarding reduction of ASI between the nicotinamide and clindamycin groups (P = 0. 5830).

Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris. No side effect was observed during the treatment. Keywords: Acne، Clindamycin، Nicotinamide، Treatment