جستجوی مقالات مرتبط با کلیدواژه « لیدوکائین » در نشریات گروه « پزشکی »

Lidocaine is the most effective anesthetic and a valuable drug for nerve pain control and management. Dexamethasone is commonly used to prevent postoperative nausea and vomiting. Dexamethasone, together with a local anesthetic, enhances the peripheral nerve block. Therefore, this study was conducted to compare the duration of anesthesia and analgesia effects after surgery in 2 anesthesia methods.

This descriptive-analytical study was conducted on 50 patients aged 18 to 70 years who were candidates for orthopedic surgery and visited the 5th Azar Medical Training Center, Gorgan, Iran during 2021. The sample was selected via convenience sampling and by checking the inclusion criteria. In group 1, 10 ml of Lidocaine 1%, and in group 2, 8 ml of 1% Lidocaine and 2 ml of dexamethasone were used as infiltration in the operation site. The average onset of analgesia and the duration of analgesia as well as postoperative pain between both anesthesia methods were determined and compared with the visual analog scale.

The average duration of anesthetic effect was significantly higher in group 2 (P<0.05). In addition, the average pain duration of the patients of group 2 had a downward trend from the time of entry to when they exited the recovery room (P<0.05).

The combination of dexamethasone and Lidocaine increased the duration of finger nerve block effect and analgesia after surgery.

 Various drugs are used as adjuvants to improve the quality of supraclavicular block method. 

 This study aims to investigate the effect of adding dexmedetomidine to lidocaine in the supraclavicular block method in patients candidate for upper extremity surgery.

 This double-blind randomized controlled clinical trial was conducted on 61 patients candidate for upper extremity fracture surgery receiving the supraclavicular block method from 2017 to 2018. They were randomly divided into two groups of lidocaine-normal saline (30 mL of 1.5% lidocaine plus normal saline) and lidocaine-dexmedetomidine (30 mL of 1.5% lidocaine plus 1 μg/kg of dexmedetomidine). The supraclavicular block characteristics and intraoperative hemodynamic changes were measured.

 There was no statistically significant difference between the two groups regarding the demographic factors. The mean age of patients was 43.09±10.92 years, and most of them were male. The mean onset time of sensory-motor blockade was faster and the duration of sensory-motor blockade and analgesia were longer in the lidocaine-dexmedetomidine group than in the other group. These differences were statistically significant. There was significant differences in hemodynamic parameters among nine assessment times in each group and between the two groups.

 Adding dexmedetomidine to lidocaine in the supraclavicular block method accelerates the blockade onset and increases the duration of blockade and analgesia after surgery without causing any considerable side effects.

Propofol is commonly used in anesthesia practice because of its rapid recovery time, but pain upon injection is one of the unfavorable complications of this drug, which can cause both physical and mental discomfort for patients. Therefore, it is important to lower the pain on injection of Propofol in patients undergoing anesthesia. As a result, the current study was conducted in order to compare the effects of lidocaine, lidocaine, and the Valsalva maneuver, and the Valsalva maneuver on decreasing the pain of Propofol injection.

 This study is a clinical trial with 111 patients. The patients were allocated into 3 groups with one group receiving lidocaine, the second group receiving lidocaine and the Valsalva maneuver , and Valsalva maneuver. The pain resulting from injecting Propofol based upon the Visual Analog Scale (VAS) score was evaluated (with 1 being no pain and 10 the most severe imaginable pain). Data were compared and analysed using proper statistical tests using SPSS version 23.

 The mean pain score in the combination group of lidocaine and Valsalva maneuver was lower than the other two groups and was equal to 0.5 ± 0.33. In addition, the mean pain scores in the lidocaine group and the Valsalva maneuver group were 4.6 ± 1.41 and7.81±1/91, respectively. The mean pain intensity in the age groups and the sexes did not show a significant difference with each other.

 The current study showed that the injection of Propofol in the three groups of the study was reduced in a similar fashion, however in the group which combined lidocaine, Valsalva, and the Valsalva maneuver, pain was lowest, but the overall score in the three groups was not statistically different.

Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Propofol in patients Undergoing surgery.

In this double-blind randomized clinical trial study, 80 patients aged 18 to 65 years were randomly blocked and assigned into four groups including Lidocaine, Ketamine, Magnesium Sulfate and Normal Saline. The pain was measured with the Ambesh Score. Hemodynamic changes of patients were evaluated in 1, 3, and 5 minutes.

The patients in Lidocaine, Ketamine, and Magnesium Sulfate groups with 75%, 70%, and 55%, respectively, did not feel pain after Propofol injection compared to Normal Saline group (25%) (P<0.05). The mean time trend of Systolic and diastolic blood pressure and mean arterial blood pressure between the studied groups were significant (P<0.05).

The use of Lidocaine or Ketamine during Propofol injection can be effective in reducing pain during injection in patients undergo surgery.

Curettage is one of the most common gynecological surgeries in women. Its complication is pain which increases dissatisfaction in patients. Therefore, it is necessary to find a way to treat this complication. This study was performed with aim to compare the effects of three methods of using lidocaine gel in the cervix, intrauterine injection of lidocaine, and a combination of two methods to reduce pain during curettage.

This clinical trial study was performed in 2017 on 120 patients candidates for curettage in Qazvin Kosar Hospital. Patients were randomly divided into three groups of topical lidocaine gel in the cervix, intrauterine injection of lidocaine and a combination of these two methods, and the drugs were prescribed before curettage. Vital signs and pain were recorded in patients and other information was collected by completing the questionnaire. Data analysis was performed using statistical software (version 22) and chi-square and ANOVA tests. P<0.05 was considered statistically significant.

The intrauterine and intra cervical injection of lidocaine (0.3±0.72) and then injection of intra cervical lidocaine (0.45±0.84) alone significantly reduced pain during curettage in women (P=0.04). On the other hand, no severe hemodynamic changes were observed in these patients. No complications such as nausea and vomiting and no instability of vital signs were observed in any of the groups (P>0.05).

Intrauterine administration along with addition of topical lidocaine gel to the cervix can be used as a simple, low-cost, and safe method as to control pain during and after curettage.

Tonsillectomy is one of the most common surgeries in children, which is associated with pain and bleeding after the operation. This study was conducted to investigate the effect of lidocaine-epinephrine administration in controlling complications after tonsillectomy.

This clinical trial was conducted on 109 patients aged 5 to 18, who had referred to Kowsar Hospital in Sanandaj for tonsillectomy. After dividing the patients randomly, 40 mg of 1% lidocaine and 5 μg of epinephrine (a volume of 5 ml) were injected into the tonsillar bed in the intervention group before the surgery, but in the patients of the control group, surgery was started without lidocaine-epinephrine administration. Blood pressure and heart rate of the patients before, during and after surgery, and pain intensity based on Wong-Baker Faces Pain Scale at minutes 30 and 60 and 6, 12 and 24 hours after surgery, and the amount of bleeding during and after surgery were recorded and compared by calculating the volume of suction and blood pads as well as the length of stay in recovery.

The mean amount of bleeding in the intervention group was 65.5±47.1 ml and in the control group was 113.7±45.7 ml (p=0.0001). The mean pain intensity and hemodynamic changes at minutes 30 and 60, and 6, 12 and 24 hours after surgery in the intervention group were lower than the control group and showed statistically significant differences (p=0.0001). The mean time of discharge from recovery in the intervention group was 0.35±23.2 minutes and in the control group was 50.4±17.5 minutes (p=0.0001).

Based on the results of this study, it seems that the administration of lidocaine-epinephrine in the tonsil bed before tonsillectomy can reduce the amount of pain, bleeding, and hemodynamic changes during and after surgery, and the patient can recover sooner.

Stability of hemodynamics and physiological parameter after open heart surgery is one of the most important reasons for success in surgery. Tracheal suctioning causes hemodynamics and physiological instability. Patients should be sedated after open heart surgery, so they need tracheal suctioning. Therefore, in this study we aimed to investigate the effect of carina anesthesia by topical administration of lidocaine in endotracheal suctioning on hemodynamic parameters and bucking in adult patients after heart surgery.

In a double-blind randomized clinical trial, adult patients undergoing coronary and valve surgery through the fall 2020 in Rajaie Cardiovascular Medical and Research Center were randomly assigned in two groups of 34 patients. Group A received tracheal suction with 4 cc of 2% lidocaine in intratracheally and group B received tracheal suction with 4 cc of 0.9% normal saline intratracheally. Changes in hemodynamic parameters (HR, CVP, MAP), bucking and Spo2, at 2 Minutes before, during and 2 minutes after suctioning were studied at intensive care unit (ICU). Data were analyzed using two-way repeated measures ANOVA.

There was a statistically significant difference between lidocaine group and normal saline group in all hemodynamic parameters and bucking during and 2 minutes after suctioning (p <0.05), but there was no statistically significant difference between the two groups in Spo2 (P>0.05).

According to the results of the study, it can be concluded that the use of intratracheal lidocaine during endotracheal suctioning in cardiac surgery patients reduces changes in hemodynamic parameters and bucking during and after endotracheal suctioning.

Gastrointestinal endoscopy is an essential method for evaluating and treating gastrointestinal disorders. Sedation in endoscopy aims to safely and effectively control pain and anxiety, to provide an appropriate degree of amnesia or to reduce consciousness, and to improve endoscopy, especially in medical cases,always been a critical issue. Propofol is an effective sedative but does not cause adequate analgesia. To overcome the side effects of lidocaine and ketamine in different doses has been used to increase anxiety, sedation and recovery, but different results have been obtained from different studies. Therefore, the aim of this study was to compare the sedative effect of propofol-ketamine with propofol-ketamine with lidocaine spray in endoscopy.

A clinical trial study was performed on 144 patients who were candidates for outpatient endoscopy in the endoscopy ward of Imam Khomeini Hospital and the patients were randomly divided into two groups. After taking the patient's history, in the first group 0.5 kg / mg propofol with 0.5 kg / mg ketamine and in the second groupin the second group, 2 puffs of 10% lidocaine spray equal to 20 mg were sprayed on the oropharynx. Then 0.5 mg / kg propofol and 0.5 mg / kg ketamine were injected. Then sedation, apnea, nausea and clinical findings in patients were evaluated and compared.

In this study, the sex distribution of patients undergoing surgery was 46.75% female and 53.25% male. In this study, the mean age of patients was 49.40 years and the two groups were matched for age and gender. The mean duration of anesthesia was 15.84 minutes and the mean endoscopic duration of patients was 13.34 minutes. There was no significant difference between the distribution of anesthesia duration and endoscopic duration in the two groups. According to the study, sedation was higher among patients receiving propofol, ketamine, and lidocaine spray.There is no significant difference in systolic blood pressure levels between the two groups. Heart rate was significantly lower during the duration of anesthesia in the propofol, ketamine, and lidocaine groups. Blood oxygen levels were significantly higher in the propofol, ketamine and lidocaine group. There is no significant difference between apnea and nausea in patients in the two groups and the recovery time in patients receiving propofol and ketamine and lidocaine is longer than the propofol and ketamine groups.

Adding topical lidocaine spray to the propofol-ketamine drug combination for endoscopic procedures increases the degree of sedation in endoscopy.

The aim of this study was to evaluate the effect of intracameral lidocaine injection on hemodynamic parameters and pain intensity during and after cataract surgery under intravenous sedation and topical anesthesia.

This clinical trial included 62 patients randomly divided into two groups of 31; the intervention group received intracameral lidocaine with topical tetracaine, and the placebo group received intracameral sterile balance sodium solution (BSS) with topical tetracaine. Baseline and intraoperative and postoperative hemodynamic variables were recorded, and pain intensity were recorded and analyzed upon entering recovery and at different intervals up to 24 hours after the surgery.

Reported pain intensity decreased significantly In both groups over time (P < 0.050). Patients’ pain in the intervention group was significantly lower in comparison to the control group (P < 0.050); but no significant difference was observed between the hemodynamic variables in two groups (P > 0.05)

The present study shows that intracameral lidocaine is effective in controlling postoperative pain in patients undergoing cataract surgery without any considerable hemodynamic side effects.

 The effects of anesthesia techniques and anesthetics on different systems and organs of the body, especially the immune system, in older patients undergoing surgery, have always been of interest to researchers. This study aims to compare the effects of general anesthesia with isoflurane and spinal anesthesia with lidocaine on oxidative and antioxidant parameters in older patients with inguinal hernia surgery.

This is a double-blinded randomized clinical trial with parallel design conducted on 70 older patients referred to the surgery department of hospitals in Tehran, Iran during 2018-2019. They were randomly divided into two groups of 35; the first group received general anesthesia with isoflurane and the second group received spinal anesthesia with lidocaine. Blood sampling was performed in two stages; one day before and one day after surgery. Advanced Glycation End Products (AGEs), Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), oxidized Low-Density Lipoprotein (LDL), Ferric-Reducing Ability of Plasma (FRAP), glutathione peroxidase, superoxide dismutase and catalase levels were measured before and after anesthesia using standard methods. Collected data were analyzed in SPSS v.22 software.

 The Mean±SD age of patients in the lidocaine group was 69.94±8.31 years and in the isoflurane as 70.23±4.98 (P>0.81). In the isoflurane group, there was a significant difference between pre- and postoperative levels of AOPP, MDA, oxidized LDL, FRAP, catalase, glutathione peroxidase and superoxide dismutase. In the lidocaine group, this difference was significant  in MDA, oxidized LDL, catalase and superoxide dismutase. 

 Given the positive effects of isoflurane on oxidative and antioxidant parameters in older patients with inguinal hernia surgery, it is recommended that this anesthetic be considered in the selection of anesthesia methods and drugs for this group of older patients.

Hematoma block (HB) is a technique for local anesthesia injection between fractured bone fragments. The aim of the present study was to compare the effect of HB with injection of lidocaine with and without ketamine on reduction of pain, blood pressure, and heart rate in patients with distal radius fracture.

In this randomized double-blind clinical trial study, a total of 60 patients with distal radius fracture were randomly selected and divided in two equal groups. Patients in the first group underwent HB with injection of 8 ml lidocaine 2%, and patients in group B underwent HB with injection of 8 ml lidocaine 2% plus ketamine (0.5 mg/kg). The intensity of pain, blood pressure, and heart rate were measured before, during, and after 1 and 6 hours of bone placement.

There was no significant difference in the mean pain between the two groups before bone reduction (P = 0.87). But, the mean pain significantly was lower in group B during (P = 0.004) and 1 (P < 0.001) and 6 (P < 0.001) hours after bone reduction.

According to our data, it can be concluded that combination of ketamine and lidocaine has better analgesic effect in HB technique in patients with distal radius fracture. However, further studies should be conducted to confirm our data.

Pain is the most common post-tonsillectomy complaint in children, whose insufficient relief can result in a number of complications. The present study aimed to determine and compare the effects of the local injection of bupivacaine and lidocaine-epinephrine mixture on post-tonsillectomy pain.

In this double-blind randomized clinical trial, 87 candidate children for tonsillectomy aged 4-10 years were selected through non-probability convenience sampling. The subjects were randomly assigned to 3 groups. All patients in the three groups underwent identical general anesthesia and cold knife dissection procedures. Five minutes before incision, children in the intervention groups received 2 mL of bupivacaine 0.125% and 2 mL of a mixture of lidocaine 1% and epinephrine (1:200,000), respectively, through tonsillar and peritonsillar local injection. Pain intensity was assessed 2, 4, 6, and 8 hours after surgery using the Wong-Baker Faces Pain Rating Scale. Data were analyzed in SPSS 21 using descriptive and inferential statistics at a 95% confidence interval and 0.05 significance level.

The postoperative pain intensity ranged from 4 to 8 in the bupivacaine-receiving group, from 5 to 8 in the lidocaine-epinephrine mixture-receiving group, and from 6 to 10 in the control group. A statistically significant difference was observed in the median pain intensity among the three groups of children participating in the study (p=0.001). Although the pain intensity in the bupivacaine-receiving children was lower than lidocaine-epinephrine mixture-receiving children 2, 4, 6, and 8 hours after surgery, the difference was only statistically significant 2 and 4 hours postoperatively (p=0.001) and no statistically significant difference was observed in other times (p>0.05). There was a significant difference in the pain intensity between the two intervention groups and the control group at all times (2, 4, 6, and 8 hours after surgery) (p=0.001).

Although local injection of bupivacaine and lidocaine-epinephrine mixture reduced post-tonsillectomy pain in children, there was no difference in their effect on pain reduction except 2 and 4 hours postoperatively.

The pain after the surgery is an important clinical problem. Until now a lot of methods for reducing pain after surgery have been evaluated. Because of the high prevalence of cesarean section and this point that pain after cesarean section can influence the healthy state of mothers and infants, this study with purpose of comparing of outcome of incisional infiltration with Lidocaine and Epinephrine versus Lidocaine in the end of cesarean section has been planned.

This study has been performed on 100 pregnant women with term pregnancy that were candidate for elective cesarean with spinal anesthesia. Patients were randomly divided to two groups including, group of 20 ml 2% Lidocaine or 20 ml solution of 1/4 of 1 mg/ml Epinephrine in 50cc of 2% Lidocaine (1/200000 dilution) that has been infiltrated in the subcutaneous after cesarean and before closing the skin. The measure of pain and narcotic use after surgery, the time of first lactating, to get out of bed , and discharge time of patients from hospital were compared between two groups with statistical tests, independent t, fisher exact test , and chi-square .

The results of this study showed that patients who have received Lidocaine and Epinephrine in the incisional site after cesarean versus patients who have received Lidocaine alone meaningfully started lactating sooner (P=0.018) and discharged sooner from hospital (P=0.010). Also, these individuals experienced less pain intensity from the 4 hours postoperatively until the end of the first day after the operation, compared to the lidocaine group (P<0.001), and the use of pethidine on the first day was less than that of the opposite group (P<0.001).

It seems adding Epinephrine to the local anesthetics like Lidocaine can prolong the effect of anesthetics and can reduce the doses of narcotic use after surgery and also can reduce the time of first lactating and discharge from hospital.

Pain during injection of local anesthesia causes fear and anxiety in many patients that could be a reason why patients avoid regular dental treatment. Previous studies have reported the effect of warming anesthetic solutions in various areas such as skin, plastic surgery, and cataract surgery. The purpose of this study was to evaluate the effect of warming anesthetic solution on the control of pain perception during maxillary infiltration in same patient erffering to faculty of Dentistry, Tehran Medical Sciences of Islamic Azad University at 2018.

This research was based on clinical trial,split mouth type. The patients with indication of anesthesia injection for both sides of maxilla which were agreed to participation of this study, considered as study samples.  2 percent Lidocaine (Daroopakhsh-Iran) was heated by (Tommee-Teppee-England) boiler to 40°C and the injection was performed at 37°C in the experimental group, whereas the opposite side, as the control, served 21°C (room temperature) injection. Either side of maxilla was conducted randomly as experimental group (warm injection) and control group (room temperature injection). The intensity of pain perceived during the injection was assessed by 100 mm Visual Analog Scale and statistically analyzed by the MANN-U-WHITNEY test.

Evaluation was made on 16 patients and regarding to type of study, 32 sides. Of samples, 7 male and 13 females were present and age average of them was 36.1±12.98 years old. VAS scores in the control group (room temperature injection) was 38.5±28.5 and in the experimental group (warm injection) was 27.5±20.9. Pain perception was 75% in the control group and 25% in the experimental group (P <0.01).

Warming local anesthetic solution prior to injection can efficiently reduce the pain compared to its use at room temperature.

The present study aimed to compare analgesic effects of IV lidocaine vs. IV morphine on the management and relief of acute pain caused by the extremity trauma.

The present study was a triple-blind randomized clinical trial that was conducted in the emergency department of Peymanieh Hospital of Jahrom. Patients aged 16 to 65 with acute extremity traumas and the need for pain control were eligible for the study. Meaningly, one group received IV Lidocaine (1.5 mg/kg) and another group received IV Morphine (0.1 mg/kg). Pain scores, side effects, and vital signs were evaluated in the admission, and 15, 30, 45, and 60 minutes after the injection. Data were analyzed by descriptive and inferential statistical tests in SPSS software at a significant level of P< 0.05.

60 patients with a mean age of 35.31 ± 11.10 years were included in the study. Correspondingly, demographic characteristics and pain scores were similar in both groups. Median pain was higher in the intravenous morphine group than the Lidocaine group at the 15th minute after the injection (P= 0.035), but it was higher in the Lidocaine group than the IV morphine group at the 60th minute after the injection (P= 0.045). There was no significant difference between research groups at other times. Furthermore, there was a significant difference between IV Lidocaine and morphine in terms of pulse rates during the drug injection (P= 0.012), but no significant difference was seen in terms of their side effects (P>0.05).

Based on the research results, IV Lidocaine could be considered as an appropriate alternative for the emergency pain management in the emergency department.

Intravenous regional anesthesia is a technique developed by the use of tourniquet and intravenous injection of anesthetic drug in the distal areas of the surgical region of the limbs. The aim of this study was to compare the onset of anesthesia induced by two methods of lidocaine use in regional intravenous anesthesia of the upper extremity.

This single-blind clinical trial study was performed on 40 patients who referred to Bohlool hospital in Gonabad for forearm surgery. Samples were randomly divided into two receiving 40 ml lidocaine 0.5% and 20 ml lidocaine 1%. The research tool was a Researcher-made checklist and a Visual Analoge Scale (VAS). Fisher's exact test, independent and pair t-test were used for data analysis at a significance level of less than 0.05.

The results showed that the interval between the injection of anesthesia until the start of complete anesthesia was significantly shorter in the 20 ml lidocaine 1% recipient group compared to the 40 ml lidocaine 0.5% recipient group (p0.05).

Regional intravenous anesthesia is induced by 20 ml lidocaine 1% faster than 40 ml lidocaine 0.5%.Keywords: Lidocaine, Intravenous, Regional anesthesia, Upper extremity

In experimental studies, proper choice of anesthesia method is important for both validity of results and improving the rate of success and mortality. In current study, we examined the effects of lidocaine combined with chloral hydrate for induction of anesthesia in a rat model of ischemic stroke.

In this research, 30 male rats were studied as sham, chloral hydrate, and chloral hydrate + lidocaine groups. Focal cerebral ischemia was induced by intraluminal filament method. Twenty four hours following ischemia, the animals were assessed for sensorimotor neurological deficits and infarct volume. Coronal sections of the brain tissue were stained using triphenyltetrazolium chloride and quantified by an image analysis system.

Combination of lidocaine and chloral hydrate for induction of anesthesia resulted in better sensorimotor performance compared with chloral hydrate alone (P<0.01), while no significant different was found between these two groups in infarct volume (P=0.41). Additionally, combination of lidocaine with chloral hydrate produced safe anesthesia in animals with low mortality rate.

Combination of lidocaine with chloral hydrate produced safe anesthesia and analgesia, better sensorimotor performance, and low mortality rate in the animals studied.

Common complications of intubation is cough and sore throat after surgery, which increase the complications and dissatisfaction of patients, therefore, it is necessary to find a way to treat this complication. Therefore, the aim of this study was to evaluate the effect of lidocaine injection with two different concentrations (2% and 4%) in the tracheal cuff on cough and sore throat after surgery and compared with control group (normal saline).

This study was performed on 96 patients undergoing surgery (32 patients in each group). Patients were randomly assigned into three groups (2 to 5 cc lidocaine 2%, lidocaine 4%, and normal saline) and the drugs were prescribed preoperatively in cuff of the endotracheal tube. Vital signs, sore throats and frequency of coughing were recorded in the patients. Chi-square and ANOVA tests were used to compare the data.

The mean score of pain in recovery and 24 hours after extubation in the lidocaine group was 4% and was the highest in the normal saline group (P = 0.002 and P = 0.019). The prevalence of cough after 12 and 24 from extubation in the lidocaine 4% group (2.6% and 0 respectively) and in the normal saline group was highest (37.5% and 25% respectively) (P=0.003 and P=0.007, respectively).

The results of our study showed that the prevalence of cough and the mean pain in patients receiving lidocaine 4% was significantly better than the 2% and normal saline groups, and also no other complications such as hemodynamic changes was not observed in the three groups.

Propofol is an intravenous anesthetic drug that has been widely used in outpatient and short-term surgery due to its rapid recovery. However, pain during propofol injection can cause discomfort in 28 to 91% of patients. Various sources have argued that the effects of hydrocortisone and lidocaine on pain during propofol injection are contradictory. The present study was investigated the comparison of effect of hydrocortisone and lidocaine on pain during propofol injection.

In a randomized double-blind clinical trial, 150 patients, aged 15-65 years with ASA I and II physical grade who were candidates for elective surgery under general anesthesia at Shahid Mohammadi Hospital in Bandar Abbas in 2019 were enrolled. They were, randomly divided into 3 groups of 50 subjects'. Group A received lidocaine 2%, 1 mg / kg; group B received 25 mg hydrocortisone; and group C received 5 ml saline. The severity and incidence of pain after propofol injection were evaluated. Data were analyzed by SPSS software, version 19 and analyzed by independent t-test and chi-square or fisher exact test. P-values ​​less than 0.05 were considered as significant.

There was a significant difference in incidence of pain during propofol injection between the three groups (lidocaine and hydrocortisone, lidocaine and hydrocortisone and with normal saline) (p <0.001). There was also a significant difference in pain severity between the lidocaine and hydrocortisone with normal saline groups, while there was no significant difference between the lidocaine and hydrocortisone groups (p= 0.615). The effect of hydrocortisone and lidocaine on pain was not significant according to sex, age and weight.

Hydrocortisone and lidocaine reduce pain during propofol injection and the effect of lidocaine was more than hydrocortisone. However, using of these medications may be able to reduce the pain resulted during propofol injection.